Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score

Z Yilmaz; T Renton; Y Yiangou; J Zakrzewska; I P Chessell; C Bountra; P Anand

doi:10.1016/j.jocn.2006.09.002

Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score

Z Yilmaz, T Renton, Y Yiangou, J Zakrzewska, I P Chessell, C Bountra, P Anand

Centre for Oral, Clinical & Translational Sciences

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219 Citations (Scopus)

Abstract

Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres penetrating the epithelium were less abundant in BMS (p

Original language	English
Pages (from-to)	864-71
Number of pages	8
Journal	Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/j.jocn.2006.09.002
Publication status	Published - Sept 2007

Keywords

TRPV Cation Channels
Humans
Pain Measurement
Aged
Biopsy
Nerve Growth Factor
Sodium Channels
Aged, 80 and over
Adult
Trigeminal Nerve Diseases
Tongue
Gene Expression Regulation
Middle Aged
Adolescent
NAV1.8 Voltage-Gated Sodium Channel
Female
Male
Neurofilament Proteins
Burning Mouth Syndrome
Nerve Fibers

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Yilmaz, Z., Renton, T., Yiangou, Y., Zakrzewska, J., Chessell, I. P., Bountra, C., & Anand, P. (2007). Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 14(9), 864-71. https://doi.org/10.1016/j.jocn.2006.09.002

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title = "Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score",

abstract = "Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres penetrating the epithelium were less abundant in BMS (p",

keywords = "TRPV Cation Channels, Humans, Pain Measurement, Aged, Biopsy, Nerve Growth Factor, Sodium Channels, Aged, 80 and over, Adult, Trigeminal Nerve Diseases, Tongue, Gene Expression Regulation, Middle Aged, Adolescent, NAV1.8 Voltage-Gated Sodium Channel, Female, Male, Neurofilament Proteins, Burning Mouth Syndrome, Nerve Fibers",

author = "Z Yilmaz and T Renton and Y Yiangou and J Zakrzewska and Chessell, {I P} and C Bountra and P Anand",

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Yilmaz, Z , Renton, T, Yiangou, Y, Zakrzewska, J, Chessell, IP, Bountra, C & Anand, P 2007, 'Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score', Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, vol. 14, no. 9, pp. 864-71. https://doi.org/10.1016/j.jocn.2006.09.002

Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. / Yilmaz, Z ; Renton, T; Yiangou, Y et al.
In: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Vol. 14, No. 9, 09.2007, p. 864-71.

Research output: Contribution to journal › Article › peer-review

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AU - Bountra, C

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Yilmaz Z , Renton T, Yiangou Y, Zakrzewska J, Chessell IP, Bountra C et al. Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2007 Sept;14(9):864-71. doi: 10.1016/j.jocn.2006.09.002

Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score

Abstract

Keywords

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