@article{8d699c9d26684317843ed636e97d00c3,
title = "Candida albicans and candidalysin in inflammatory disorders and cancer",
abstract = "As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.",
keywords = "Candida albicans, candidalysin, gut barrier, IL-17, mucosal disease",
author = "Jemima Ho and Giorgio Camilli and Griffiths, {James S.} and Richardson, {Jonathan P.} and Nessim Kichik and Naglik, {Julian R.}",
note = "Funding Information: J.H. conceptualised and wrote the paper; G.C. created the schematic diagram; J.G., J.P.R., N.K. and J.R.N. edited the paper. This work was supported by grants from the Wellcome Trust (214229 Z 18 Z), Biotechnology & Biological Sciences Research Council (BB/N014677/1), National Institutes of Health (R37‐DE022550), King{\textquoteright}s Health Partners Challenge Fund (R170501), the Rosetrees Trust (M680), and the NIH Research at Guys and St. Thomas{\textquoteright}s NHS Foundation Trust and the King{\textquoteright}s College London Biomedical Research Centre (IS‐BRC‐1215‐20006). Publisher Copyright: {\textcopyright} 2020 The Authors. Immunology published by John Wiley & Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
doi = "10.1111/imm.13255",
language = "English",
volume = "162",
pages = "11--16",
journal = "Immunology",
issn = "0019-2805",
publisher = "Wiley-Blackwell",
number = "1",
}
