Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci

G Hamilton; Petra Proitsi; L Jehu; A Morgan; J Williams; M C O'Donovan; M J Owen; J F Powell; S Lovestone

doi:10.1002/ajmg.b.30503

Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci

G Hamilton, Petra Proitsi, L Jehu, A Morgan, J Williams, M C O'Donovan, M J Owen, J F Powell, S Lovestone

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes-PPAR gamma, SOS2, and PCK1-with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. (c) 2007 Wiley-Liss, Inc

Original language	English
Pages (from-to)	508 - 516
Number of pages	9
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	144B
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.b.30503
Publication status	Published - 5 Jun 2007

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Hamilton, G., Proitsi, P., Jehu, L., Morgan, A., Williams, J., O'Donovan, M. C., Owen, M. J., Powell, J. F., & Lovestone, S. (2007). Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 144B(4), 508 - 516. https://doi.org/10.1002/ajmg.b.30503

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title = "Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci",

abstract = "Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes-PPAR gamma, SOS2, and PCK1-with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. (c) 2007 Wiley-Liss, Inc",

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Hamilton, G , Proitsi, P, Jehu, L, Morgan, A, Williams, J, O'Donovan, MC, Owen, MJ, Powell, JF & Lovestone, S 2007, 'Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 144B, no. 4, pp. 508 - 516. https://doi.org/10.1002/ajmg.b.30503

Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci. / Hamilton, G ; Proitsi, Petra; Jehu, L et al.
In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 144B, No. 4, 05.06.2007, p. 508 - 516.

Research output: Contribution to journal › Article › peer-review

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AU - Williams, J

AU - O'Donovan, M C

AU - Owen, M J

AU - Powell, J F

AU - Lovestone, S

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Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPAR gamma as susceptibility loci

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