Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

Salvatore Bongarzone; Nicola Raucci; Igor Camargo Fontana; Federico Luzi; Antony D Gee

doi:10.1039/d0cc00449a

Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

Salvatore Bongarzone, Nicola Raucci, Igor Camargo Fontana, Federico Luzi, Antony D Gee

School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London SE1 7EH, UK. [email protected] [email protected].

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.

Original language	English
Pages (from-to)	4668-4671
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	56
Issue number	34
Early online date	25 Mar 2020
DOIs	https://doi.org/10.1039/d0cc00449a
Publication status	Published - 30 Apr 2020

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abstract = "A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.",

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AU - Luzi, Federico

AU - Gee, Antony D

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AB - A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.

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DO - 10.1039/d0cc00449a

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JO - Chemical communications (Cambridge, England)

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ER -

Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

Abstract

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