CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses

G Banfield; H Watanabe; G Scadding; M R Jacobson; S J Till; D A Hall; D S Robinson; C M Lloyd; K T Nouri-Aria; S R Durham

doi:10.1111/j.1398-9995.2010.02327.x

CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses

G Banfield, H Watanabe, G Scadding, M R Jacobson, S J Till, D A Hall, D S Robinson, C M Lloyd, K T Nouri-Aria, S R Durham

King's College London

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

CC Chemokine receptor 4 (CCR4) is preferentially expressed on Th2 lymphocytes. CCR4-mediated inflammation may be important in the pathology of allergic rhinitis. Disruption of CCR4 - ligand interaction may abrogate allergen-induced inflammation.

Original language	English
Pages (from-to)	1126-33
Number of pages	8
Journal	Allergy
Volume	65
Issue number	9
DOIs	https://doi.org/10.1111/j.1398-9995.2010.02327.x
Publication status	Published - Sept 2010

Keywords

Humans
Biopsy
Th2 Cells
Receptors, CCR4
Inflammation
Rhinitis, Allergic, Perennial
Administration, Intranasal
Allergens
Rhinitis, Allergic, Seasonal
Adult
Hypersensitivity, Immediate
Nasal Mucosa
Time Factors
Female
Male

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10.1111/j.1398-9995.2010.02327.x

Cite this

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title = "CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses",

abstract = "CC Chemokine receptor 4 (CCR4) is preferentially expressed on Th2 lymphocytes. CCR4-mediated inflammation may be important in the pathology of allergic rhinitis. Disruption of CCR4 - ligand interaction may abrogate allergen-induced inflammation.",

keywords = "Humans, Biopsy, Th2 Cells, Receptors, CCR4, Inflammation, Rhinitis, Allergic, Perennial, Administration, Intranasal, Allergens, Rhinitis, Allergic, Seasonal, Adult, Hypersensitivity, Immediate, Nasal Mucosa, Time Factors, Female, Male",

author = "G Banfield and H Watanabe and G Scadding and Jacobson, {M R} and Till, {S J} and Hall, {D A} and Robinson, {D S} and Lloyd, {C M} and Nouri-Aria, {K T} and Durham, {S R}",

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AU - Banfield, G

AU - Watanabe, H

AU - Scadding, G

AU - Jacobson, M R

AU - Till, S J

AU - Hall, D A

AU - Robinson, D S

AU - Lloyd, C M

AU - Nouri-Aria, K T

AU - Durham, S R

PY - 2010/9

Y1 - 2010/9

N2 - CC Chemokine receptor 4 (CCR4) is preferentially expressed on Th2 lymphocytes. CCR4-mediated inflammation may be important in the pathology of allergic rhinitis. Disruption of CCR4 - ligand interaction may abrogate allergen-induced inflammation.

AB - CC Chemokine receptor 4 (CCR4) is preferentially expressed on Th2 lymphocytes. CCR4-mediated inflammation may be important in the pathology of allergic rhinitis. Disruption of CCR4 - ligand interaction may abrogate allergen-induced inflammation.

KW - Humans

KW - Biopsy

KW - Th2 Cells

KW - Receptors, CCR4

KW - Inflammation

KW - Rhinitis, Allergic, Perennial

KW - Administration, Intranasal

KW - Allergens

KW - Rhinitis, Allergic, Seasonal

KW - Adult

KW - Hypersensitivity, Immediate

KW - Nasal Mucosa

KW - Time Factors

KW - Female

KW - Male

U2 - 10.1111/j.1398-9995.2010.02327.x

DO - 10.1111/j.1398-9995.2010.02327.x

M3 - Article

C2 - 20148806

VL - 65

SP - 1126

EP - 1133

JO - Allergy

JF - Allergy

IS - 9

ER -

CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses

Abstract

Keywords

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