TY - JOUR
T1 - CCL4 induces inflammatory signalling and barrier disruption in the neurovascular endothelium
AU - Estevao, Carolina
AU - Bowers, Chantelle E.
AU - Luo, Ding
AU - Sarker, Mosharraf
AU - Hoeh, Alexandra eva
AU - Frudd, Karen
AU - Turowski, Patric
AU - Greenwood, John
PY - 2021/12/18
Y1 - 2021/12/18
N2 - During neuroinflammation many chemokines alter the function of the blood-brain barrier (BBB) that regulates the entry of macromolecules and immune cells into the brain. As the milieu of the brain is altered, biochemical and structural changes contribute to the pathogenesis of neuroinflammation and may impact on neurogenesis. The chemokine CCL4, previously known as MIP-1β, is upregulated in a wide variety of central nervous system disorders, including multiple sclerosis, where it is thought to play a key role in the neuroinflammatory process. However, the effect of CCL4 on BBB endothelial cells (ECs) is unknown.
AB - During neuroinflammation many chemokines alter the function of the blood-brain barrier (BBB) that regulates the entry of macromolecules and immune cells into the brain. As the milieu of the brain is altered, biochemical and structural changes contribute to the pathogenesis of neuroinflammation and may impact on neurogenesis. The chemokine CCL4, previously known as MIP-1β, is upregulated in a wide variety of central nervous system disorders, including multiple sclerosis, where it is thought to play a key role in the neuroinflammatory process. However, the effect of CCL4 on BBB endothelial cells (ECs) is unknown.
U2 - 10.1016/j.bbih.2021.100370
DO - 10.1016/j.bbih.2021.100370
M3 - Article
SN - 2666-3546
VL - 18
JO - Brain, Behavior, & Immunity - Health
JF - Brain, Behavior, & Immunity - Health
M1 - 100370
ER -