CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection

W M J M Bogers; L A Bergmeier; H Oostermeijer; P ten Haaft; Y Wang; C G Kelly; M Singh; J L Heeney; T Lehner

doi:10.1016/j.vaccine.2004.02.050

CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection

W M J M Bogers, L A Bergmeier, H Oostermeijer, P ten Haaft, Y Wang, C G Kelly, M Singh, J L Heeney, T Lehner

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV We targeted the SIV CCR5 coreceptor in a combined CCR5-SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2974 - 2984
Number of pages	11
Journal	Vaccine
Volume	22
Issue number	23-24
DOIs	https://doi.org/10.1016/j.vaccine.2004.02.050
Publication status	Published - 13 Aug 2004

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10.1016/j.vaccine.2004.02.050

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title = "CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection",

abstract = "Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV We targeted the SIV CCR5 coreceptor in a combined CCR5-SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV. (C) 2004 Elsevier Ltd. All rights reserved.",

author = "Bogers, {W M J M} and Bergmeier, {L A} and H Oostermeijer and {ten Haaft}, P and Y Wang and Kelly, {C G} and M Singh and Heeney, {J L} and T Lehner",

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T1 - CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection

AU - Bogers, W M J M

AU - Bergmeier, L A

AU - Oostermeijer, H

AU - ten Haaft, P

AU - Wang, Y

AU - Kelly, C G

AU - Singh, M

AU - Heeney, J L

AU - Lehner, T

PY - 2004/8/13

Y1 - 2004/8/13

N2 - Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV We targeted the SIV CCR5 coreceptor in a combined CCR5-SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV. (C) 2004 Elsevier Ltd. All rights reserved.

AB - Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV We targeted the SIV CCR5 coreceptor in a combined CCR5-SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV. (C) 2004 Elsevier Ltd. All rights reserved.

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U2 - 10.1016/j.vaccine.2004.02.050

DO - 10.1016/j.vaccine.2004.02.050

M3 - Article

SN - 1873-2518

VL - 22

SP - 2974

EP - 2984

JO - Vaccine

JF - Vaccine

IS - 23-24

ER -

CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection

Abstract

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