CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Mark Bower; Martin Fisher; Teresa Hill; Iain Reeves; John Walsh; Chloe Orkin; Andrew N. Phillips; Loveleen Bansi; Richard Gilson; Philippa Easterbrook; Margaret Johnson; Brian Gazzard; Clifford Leen; Deenan Pillay; Achim Schwenk; Jane Anderson; Kholoud Porter; Mark Gompels; Caroline A. Sabin

doi:10.3324/haematol.2008.002691

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Mark Bower, Martin Fisher, Teresa Hill, Iain Reeves, John Walsh, Chloe Orkin, Andrew N. Phillips, Loveleen Bansi, Richard Gilson, Philippa Easterbrook, Margaret Johnson, Brian Gazzard, Clifford Leen, Deenan Pillay, Achim Schwenk, Jane Anderson, Kholoud Porter, Mark Gompels, Caroline A. Sabin

King's College London

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin's lymphoma among HIV-infected individuals. We described trends in the incidence of systemic non-Hodgkin's lymphoma in the UK CHIC Study from 19962006 and evaluated the association between immunosuppression and development of systemic non-Hodgkin's lymphoma: 286/23,155 (1.2%) individuals developed an AIDS-defining lymphoma (258 systemic). Younger age, receipt of highly active antiretroviral therapy and later calendar year were all independently associated with a reduced risk of systemic non-Hodgkin's lymphoma. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma, in patients who had (RR per log(2)(cells/mm(3)) higher: 0.62) and had not (0.70) received highly active antiretroviral therapy. Associations with other measures of immunosuppression, including nadir CD4 count, experience and duration of severe immunosuppression, were generally weaker. Earlier highly active antiretroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma.

Original language	English
Pages (from-to)	875 - 880
Number of pages	6
Journal	Haematologica
Volume	94
Issue number	6
DOIs	https://doi.org/10.3324/haematol.2008.002691
Publication status	Published - Jun 2009

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10.3324/haematol.2008.002691

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Bower, M., Fisher, M., Hill, T., Reeves, I., Walsh, J., Orkin, C., Phillips, A. N., Bansi, L., Gilson, R., Easterbrook, P., Johnson, M., Gazzard, B., Leen, C., Pillay, D., Schwenk, A., Anderson, J., Porter, K., Gompels, M., & Sabin, C. A. (2009). CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK. Haematologica, 94(6), 875 - 880. https://doi.org/10.3324/haematol.2008.002691

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title = "CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK",

abstract = "Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin's lymphoma among HIV-infected individuals. We described trends in the incidence of systemic non-Hodgkin's lymphoma in the UK CHIC Study from 19962006 and evaluated the association between immunosuppression and development of systemic non-Hodgkin's lymphoma: 286/23,155 (1.2%) individuals developed an AIDS-defining lymphoma (258 systemic). Younger age, receipt of highly active antiretroviral therapy and later calendar year were all independently associated with a reduced risk of systemic non-Hodgkin's lymphoma. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma, in patients who had (RR per log(2)(cells/mm(3)) higher: 0.62) and had not (0.70) received highly active antiretroviral therapy. Associations with other measures of immunosuppression, including nadir CD4 count, experience and duration of severe immunosuppression, were generally weaker. Earlier highly active antiretroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma.",

author = "Mark Bower and Martin Fisher and Teresa Hill and Iain Reeves and John Walsh and Chloe Orkin and Phillips, {Andrew N.} and Loveleen Bansi and Richard Gilson and Philippa Easterbrook and Margaret Johnson and Brian Gazzard and Clifford Leen and Deenan Pillay and Achim Schwenk and Jane Anderson and Kholoud Porter and Mark Gompels and Sabin, {Caroline A.}",

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month = jun,

doi = "10.3324/haematol.2008.002691",

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Bower, M, Fisher, M, Hill, T, Reeves, I, Walsh, J, Orkin, C, Phillips, AN, Bansi, L, Gilson, R, Easterbrook, P, Johnson, M, Gazzard, B, Leen, C, Pillay, D, Schwenk, A, Anderson, J, Porter, K, Gompels, M & Sabin, CA 2009, 'CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK', Haematologica, vol. 94, no. 6, pp. 875 - 880. https://doi.org/10.3324/haematol.2008.002691

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T1 - CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

AU - Bower, Mark

AU - Fisher, Martin

AU - Hill, Teresa

AU - Reeves, Iain

AU - Walsh, John

AU - Orkin, Chloe

AU - Phillips, Andrew N.

AU - Bansi, Loveleen

AU - Gilson, Richard

AU - Easterbrook, Philippa

AU - Johnson, Margaret

AU - Gazzard, Brian

AU - Leen, Clifford

AU - Pillay, Deenan

AU - Schwenk, Achim

AU - Anderson, Jane

AU - Porter, Kholoud

AU - Gompels, Mark

AU - Sabin, Caroline A.

PY - 2009/6

Y1 - 2009/6

N2 - Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin's lymphoma among HIV-infected individuals. We described trends in the incidence of systemic non-Hodgkin's lymphoma in the UK CHIC Study from 19962006 and evaluated the association between immunosuppression and development of systemic non-Hodgkin's lymphoma: 286/23,155 (1.2%) individuals developed an AIDS-defining lymphoma (258 systemic). Younger age, receipt of highly active antiretroviral therapy and later calendar year were all independently associated with a reduced risk of systemic non-Hodgkin's lymphoma. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma, in patients who had (RR per log(2)(cells/mm(3)) higher: 0.62) and had not (0.70) received highly active antiretroviral therapy. Associations with other measures of immunosuppression, including nadir CD4 count, experience and duration of severe immunosuppression, were generally weaker. Earlier highly active antiretroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma.

AB - Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin's lymphoma among HIV-infected individuals. We described trends in the incidence of systemic non-Hodgkin's lymphoma in the UK CHIC Study from 19962006 and evaluated the association between immunosuppression and development of systemic non-Hodgkin's lymphoma: 286/23,155 (1.2%) individuals developed an AIDS-defining lymphoma (258 systemic). Younger age, receipt of highly active antiretroviral therapy and later calendar year were all independently associated with a reduced risk of systemic non-Hodgkin's lymphoma. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma, in patients who had (RR per log(2)(cells/mm(3)) higher: 0.62) and had not (0.70) received highly active antiretroviral therapy. Associations with other measures of immunosuppression, including nadir CD4 count, experience and duration of severe immunosuppression, were generally weaker. Earlier highly active antiretroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma.

U2 - 10.3324/haematol.2008.002691

DO - 10.3324/haematol.2008.002691

M3 - Article

VL - 94

SP - 875

EP - 880

JO - Haematologica

JF - Haematologica

IS - 6

ER -

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Abstract

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