Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units

Stefania Vergnano; Esse Mason; Zoe Smith; Nigel Kennea; Nick Embleton; Paul Clarke; Timothy Watts; Paul T. Health

doi:10.1097/INF.0b013e318224546d

Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units

Stefania Vergnano^*, Esse Mason, Zoe Smith, Nigel Kennea, Nick Embleton, Paul Clarke, Timothy Watts, Paul T. Health

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: In industrialized countries, Staphylococcus aureus (SA) is a leading cause of late-onset neonatal sepsis.

Methods: Culture-proven episodes were identified prospectively from neonatal units participating in the neonatal infection surveillance network. Demographic, risk factor, and outcome data were collected.

Results: Between 2004 and 2009, there were 117 episodes of SA infections (including 8 methicillin-resistant SA) in 116 infants from 13 units. The median gestational age and birth-weight were 27 weeks (90%

Conclusions: SA is the second most common pathogen causing late-onset neonatal infections in this neonatal network. Infants who weigh <1500 g in intensive care settings are the most vulnerable group. Clinical signs are not sufficiently distinctive to allow targeted therapy, suggesting that an antistaphylococcal agent should be part of empiric therapy for late-onset sepsis in premature infants.

Original language	English
Pages (from-to)	850-854
Number of pages	5
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	10
DOIs	https://doi.org/10.1097/INF.0b013e318224546d
Publication status	Published - Oct 2011

Keywords

neonatal
Staphylococcus aureus
bacteremia
sepsis
MRSA
INTENSIVE-CARE-UNIT
SCALDED SKIN SYNDROME
LATE-ONSET SEPSIS
SURVEILLANCE-SYSTEM
RESISTANT
INFECTIONS
COMMUNITY
BACTEREMIA
CHILDREN
DISEASE

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title = "Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units",

abstract = "Background: In industrialized countries, Staphylococcus aureus (SA) is a leading cause of late-onset neonatal sepsis. Methods: Culture-proven episodes were identified prospectively from neonatal units participating in the neonatal infection surveillance network. Demographic, risk factor, and outcome data were collected. Results: Between 2004 and 2009, there were 117 episodes of SA infections (including 8 methicillin-resistant SA) in 116 infants from 13 units. The median gestational age and birth-weight were 27 weeks (90% Conclusions: SA is the second most common pathogen causing late-onset neonatal infections in this neonatal network. Infants who weigh <1500 g in intensive care settings are the most vulnerable group. Clinical signs are not sufficiently distinctive to allow targeted therapy, suggesting that an antistaphylococcal agent should be part of empiric therapy for late-onset sepsis in premature infants.",

keywords = "neonatal, Staphylococcus aureus, bacteremia, sepsis, MRSA, INTENSIVE-CARE-UNIT, SCALDED SKIN SYNDROME, LATE-ONSET SEPSIS, SURVEILLANCE-SYSTEM, RESISTANT, INFECTIONS, COMMUNITY, BACTEREMIA, CHILDREN, DISEASE",

author = "Stefania Vergnano and Esse Mason and Zoe Smith and Nigel Kennea and Nick Embleton and Paul Clarke and Timothy Watts and Health, {Paul T.}",

year = "2011",

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doi = "10.1097/INF.0b013e318224546d",

language = "English",

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journal = "Pediatric Infectious Disease Journal",

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T1 - Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units

AU - Vergnano, Stefania

AU - Mason, Esse

AU - Smith, Zoe

AU - Kennea, Nigel

AU - Embleton, Nick

AU - Clarke, Paul

AU - Watts, Timothy

AU - Health, Paul T.

PY - 2011/10

Y1 - 2011/10

N2 - Background: In industrialized countries, Staphylococcus aureus (SA) is a leading cause of late-onset neonatal sepsis. Methods: Culture-proven episodes were identified prospectively from neonatal units participating in the neonatal infection surveillance network. Demographic, risk factor, and outcome data were collected. Results: Between 2004 and 2009, there were 117 episodes of SA infections (including 8 methicillin-resistant SA) in 116 infants from 13 units. The median gestational age and birth-weight were 27 weeks (90% Conclusions: SA is the second most common pathogen causing late-onset neonatal infections in this neonatal network. Infants who weigh <1500 g in intensive care settings are the most vulnerable group. Clinical signs are not sufficiently distinctive to allow targeted therapy, suggesting that an antistaphylococcal agent should be part of empiric therapy for late-onset sepsis in premature infants.

AB - Background: In industrialized countries, Staphylococcus aureus (SA) is a leading cause of late-onset neonatal sepsis. Methods: Culture-proven episodes were identified prospectively from neonatal units participating in the neonatal infection surveillance network. Demographic, risk factor, and outcome data were collected. Results: Between 2004 and 2009, there were 117 episodes of SA infections (including 8 methicillin-resistant SA) in 116 infants from 13 units. The median gestational age and birth-weight were 27 weeks (90% Conclusions: SA is the second most common pathogen causing late-onset neonatal infections in this neonatal network. Infants who weigh <1500 g in intensive care settings are the most vulnerable group. Clinical signs are not sufficiently distinctive to allow targeted therapy, suggesting that an antistaphylococcal agent should be part of empiric therapy for late-onset sepsis in premature infants.

KW - neonatal

KW - Staphylococcus aureus

KW - bacteremia

KW - sepsis

KW - MRSA

KW - INTENSIVE-CARE-UNIT

KW - SCALDED SKIN SYNDROME

KW - LATE-ONSET SEPSIS

KW - SURVEILLANCE-SYSTEM

KW - RESISTANT

KW - INFECTIONS

KW - COMMUNITY

KW - BACTEREMIA

KW - CHILDREN

KW - DISEASE

U2 - 10.1097/INF.0b013e318224546d

DO - 10.1097/INF.0b013e318224546d

M3 - Article

SN - 0891-3668

VL - 30

SP - 850

EP - 854

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 10

ER -

Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units

Abstract

Keywords

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