Choosing a Mouse Model of Venous Thrombosis

Jose A. Diaz; Prakash Saha; Brian Cooley; Olivia R. Palmer; Steven P. Grover; Nigel Mackman; Thomas W. Wakefield; Peter K. Henke; Alberto Smith; Brajesh K. Lal

doi:10.1161/ATVBAHA.118.311818

Choosing a Mouse Model of Venous Thrombosis

Jose A. Diaz, Prakash Saha, Brian Cooley, Olivia R. Palmer, Steven P. Grover, Nigel Mackman, Thomas W. Wakefield, Peter K. Henke, Alberto Smith, Brajesh K. Lal

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of venous thrombosis. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

Original language	English
Pages (from-to)	311-318
Number of pages	8
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1161/ATVBAHA.118.311818
Publication status	Published - 1 Mar 2019

Keywords

consensus
experimental animal models
surgical models
venous thromboembolism
venous thrombosis

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10.1161/ATVBAHA.118.311818

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abstract = "Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of venous thrombosis. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.",

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AU - Saha, Prakash

AU - Cooley, Brian

AU - Palmer, Olivia R.

AU - Grover, Steven P.

AU - Mackman, Nigel

AU - Wakefield, Thomas W.

AU - Henke, Peter K.

AU - Smith, Alberto

AU - Lal, Brajesh K.

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Choosing a Mouse Model of Venous Thrombosis

Abstract

Keywords

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