Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application

Jose A. Diaz; Prakash Saha; Brian Cooley; Olivia R. Palmer; Steven P. Grover; Nigel Mackman; Thomas W. Wakefield; Peter K. Henke; Alberto Smith; Brajesh K. Lal

doi:10.1111/jth.14413

Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application

Jose A. Diaz^*, Prakash Saha, Brian Cooley, Olivia R. Palmer, Steven P. Grover, Nigel Mackman, Thomas W. Wakefield, Peter K. Henke, Alberto Smith, Brajesh K. Lal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Summary: Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

Original language	English
Pages (from-to)	699-707
Number of pages	9
Journal	Journal of Thrombosis and Haemostasis
Volume	17
Issue number	4
Early online date	30 Mar 2019
DOIs	https://doi.org/10.1111/jth.14413
Publication status	Published - 1 Apr 2019

Keywords

deep vein thrombosis
electrolytic inferior vena cava model
femoral electrolytic model
ferric chloride model
inferior vena cava (IVC)
mouse models
recurrent venous thrombosis model
stasis model
stenosis model
venous thromboembolism (VTE)
venous thrombosis

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10.1111/jth.14413

Cite this

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title = "Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application",

abstract = "Summary: Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.",

keywords = "deep vein thrombosis, electrolytic inferior vena cava model, femoral electrolytic model, ferric chloride model, inferior vena cava (IVC), mouse models, recurrent venous thrombosis model, stasis model, stenosis model, venous thromboembolism (VTE), venous thrombosis",

author = "Diaz, {Jose A.} and Prakash Saha and Brian Cooley and Palmer, {Olivia R.} and Grover, {Steven P.} and Nigel Mackman and Wakefield, {Thomas W.} and Henke, {Peter K.} and Alberto Smith and Lal, {Brajesh K.}",

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T1 - Choosing a mouse model of venous thrombosis

T2 - a consensus assessment of utility and application

AU - Diaz, Jose A.

AU - Saha, Prakash

AU - Cooley, Brian

AU - Palmer, Olivia R.

AU - Grover, Steven P.

AU - Mackman, Nigel

AU - Wakefield, Thomas W.

AU - Henke, Peter K.

AU - Smith, Alberto

AU - Lal, Brajesh K.

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Y1 - 2019/4/1

N2 - Summary: Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

AB - Summary: Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

KW - deep vein thrombosis

KW - electrolytic inferior vena cava model

KW - femoral electrolytic model

KW - ferric chloride model

KW - inferior vena cava (IVC)

KW - mouse models

KW - recurrent venous thrombosis model

KW - stasis model

KW - stenosis model

KW - venous thromboembolism (VTE)

KW - venous thrombosis

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U2 - 10.1111/jth.14413

DO - 10.1111/jth.14413

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JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 4

ER -

Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application

Abstract

Keywords

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