Clinical PET With A Large Area Multiwire Proportional Chamber PET Camera

R. J. Ott; P. K. Marsden; M. A. Flower; S. Webb; S. Cherry; V. R. McCready; J. E. Bateman

doi:10.1016/0168-9002(88)90517-7

Clinical PET With A Large Area Multiwire Proportional Chamber PET Camera

R. J. Ott, P. K. Marsden, M. A. Flower, S. Webb, S. Cherry, V. R. McCready, J. E. Bateman

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5–10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2–3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5–10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides (18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.

Original language	English
Pages (from-to)	436-442
Number of pages	7
Journal	Nuclear Instruments & Methods In Physics Research Section A, Accelerators, Spectrometers, Detectors And Associated Equipment
Volume	269
Issue number	2
DOIs	https://doi.org/10.1016/0168-9002(88)90517-7
Publication status	Published - 10 Jun 1988

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title = "Clinical PET With A Large Area Multiwire Proportional Chamber PET Camera",

abstract = "A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5–10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2–3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5–10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides (18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.",

author = "Ott, {R. J.} and Marsden, {P. K.} and Flower, {M. A.} and S. Webb and S. Cherry and McCready, {V. R.} and Bateman, {J. E.}",

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AU - Ott, R. J.

AU - Marsden, P. K.

AU - Flower, M. A.

AU - Webb, S.

AU - Cherry, S.

AU - McCready, V. R.

AU - Bateman, J. E.

N1 - M1 - 2 Times Cited: 28

PY - 1988/6/10

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N2 - A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5–10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2–3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5–10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides (18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.

AB - A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5–10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2–3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5–10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides (18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.

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JO - Nuclear Instruments & Methods In Physics Research Section A, Accelerators, Spectrometers, Detectors And Associated Equipment

JF - Nuclear Instruments & Methods In Physics Research Section A, Accelerators, Spectrometers, Detectors And Associated Equipment

IS - 2

ER -

Clinical PET With A Large Area Multiwire Proportional Chamber PET Camera

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