TY - JOUR
T1 - Closed-loop automated oxygen control in ventilated infants born at or near term
T2 - A crossover trial
AU - Kaltsogianni, Ourania
AU - Dassios, Theodore
AU - Lee, Rebecca
AU - Harris, Christopher
AU - Greenough, Anne
N1 - Funding Information:
This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Publisher Copyright:
© 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
PY - 2023/2
Y1 - 2023/2
N2 - Aim: To determine if the use of closed-loop automated oxygen control (CLAC) reduced the incidence and duration of hypoxemic episodes (SpO2 < 92%) in ventilated infants born at or above 34 weeks of gestation. Methods: Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care (manual oxygen control) or standard care with a CLAC system (automated oxygen control) first. Results: Sixteen infants with a median (IQR) gestational age of 37.4 (36.6–38.8) weeks were studied at a median (IQR) postmenstrual age of 38.8 (37.4–39.8) weeks. During the automated oxygen control period, infants spent less time in hypoxemia (SpO2 < 92%) (p = 0.033), episodes of desaturation were shorter (p = 0.001), the time spent within target SpO2 range (92%–96%) was increased (p = 0.001), and the FiO2 delivery was lower (p = 0.018). The time spent in hyperoxemia (SpO2 > 96%) was reduced during automated oxygen control (p = 0.011), the episodes of hyperoxemia were of shorter duration (p = 0.008) and fewer manual adjustments were made to the FiO2 (p = 0.005). Conclusions: Closed-loop automated oxygen control in ventilated infants born at or near term was associated with a reduction in the incidence and duration of hypoxemic episodes with more time spent in the target oxygen range.
AB - Aim: To determine if the use of closed-loop automated oxygen control (CLAC) reduced the incidence and duration of hypoxemic episodes (SpO2 < 92%) in ventilated infants born at or above 34 weeks of gestation. Methods: Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care (manual oxygen control) or standard care with a CLAC system (automated oxygen control) first. Results: Sixteen infants with a median (IQR) gestational age of 37.4 (36.6–38.8) weeks were studied at a median (IQR) postmenstrual age of 38.8 (37.4–39.8) weeks. During the automated oxygen control period, infants spent less time in hypoxemia (SpO2 < 92%) (p = 0.033), episodes of desaturation were shorter (p = 0.001), the time spent within target SpO2 range (92%–96%) was increased (p = 0.001), and the FiO2 delivery was lower (p = 0.018). The time spent in hyperoxemia (SpO2 > 96%) was reduced during automated oxygen control (p = 0.011), the episodes of hyperoxemia were of shorter duration (p = 0.008) and fewer manual adjustments were made to the FiO2 (p = 0.005). Conclusions: Closed-loop automated oxygen control in ventilated infants born at or near term was associated with a reduction in the incidence and duration of hypoxemic episodes with more time spent in the target oxygen range.
KW - closed-loop automated oxygen delivery
KW - hyperoxemia
KW - hypoxemia
KW - term infant
UR - http://www.scopus.com/inward/record.url?scp=85143427769&partnerID=8YFLogxK
U2 - 10.1111/apa.16598
DO - 10.1111/apa.16598
M3 - Article
C2 - 36403205
AN - SCOPUS:85143427769
SN - 0803-5253
VL - 112
SP - 246
EP - 251
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 2
ER -