TY - JOUR
T1 - Closed-loop oxygen system in late preterm/term, ventilated infants with different severities of respiratory disease
AU - Kaltsogianni, Ourania
AU - Dassios, Theodore
AU - Harris, Christopher
AU - Jenkinson, Allan
AU - Lee, Rebecca Ann
AU - Sugino, Masashiro
AU - Greenough, Anne
N1 - Funding Information:
This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Publisher Copyright:
© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
PY - 2023/6
Y1 - 2023/6
N2 - Aim: To evaluate closed-loop automated oxygen control (CLAC) in ventilated infants >33 weeks of gestation with different respiratory disease severities. Methods: Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care or standard care with CLAC (Oxygenie) first. Analyses were performed of the results of infants with or without an FiO2 ≥ 0.3 and infants with congenital diaphragmatic hernia (CDH). Results: Thirty-one infants with a median (IQR) gestational age of 37.9 (37.1–38.9) weeks were studied at a median postmenstrual age (IQR) of 38.9 (37.4–39.8) weeks. In infants with an FiO2 ≥ 0.3 (n = 8), CLAC increased the time spent in target oxygen range (92–96%) by 61.6% (p = 0.018), whereas in infants with an FiO2 < 0.3, the time in target was increased by 3.8% (p = 0.019). During CLAC, only infants with an FiO2 ≥ 0.3 spent less time in hyperoxemia (SpO2 > 96%) (p = 0.012) and hyperoxemic episodes were shorter (p = 0.012). In both groups, CLAC reduced the duration of desaturations (SpO2 < 92%, p < 0.001). In CDH infants, CLAC increased the time spent in target oxygen range by 34% (p = 0.036) and the median duration of desaturations was reduced (p = 0.028). Conclusion: CLAC may be more useful in infants with more severe respiratory distress.
AB - Aim: To evaluate closed-loop automated oxygen control (CLAC) in ventilated infants >33 weeks of gestation with different respiratory disease severities. Methods: Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care or standard care with CLAC (Oxygenie) first. Analyses were performed of the results of infants with or without an FiO2 ≥ 0.3 and infants with congenital diaphragmatic hernia (CDH). Results: Thirty-one infants with a median (IQR) gestational age of 37.9 (37.1–38.9) weeks were studied at a median postmenstrual age (IQR) of 38.9 (37.4–39.8) weeks. In infants with an FiO2 ≥ 0.3 (n = 8), CLAC increased the time spent in target oxygen range (92–96%) by 61.6% (p = 0.018), whereas in infants with an FiO2 < 0.3, the time in target was increased by 3.8% (p = 0.019). During CLAC, only infants with an FiO2 ≥ 0.3 spent less time in hyperoxemia (SpO2 > 96%) (p = 0.012) and hyperoxemic episodes were shorter (p = 0.012). In both groups, CLAC reduced the duration of desaturations (SpO2 < 92%, p < 0.001). In CDH infants, CLAC increased the time spent in target oxygen range by 34% (p = 0.036) and the median duration of desaturations was reduced (p = 0.028). Conclusion: CLAC may be more useful in infants with more severe respiratory distress.
KW - closed-loop automated oxygen delivery
KW - congenital diaphragmatic hernia
KW - term infant
UR - http://www.scopus.com/inward/record.url?scp=85147577075&partnerID=8YFLogxK
U2 - 10.1111/apa.16678
DO - 10.1111/apa.16678
M3 - Article
C2 - 36656138
AN - SCOPUS:85147577075
SN - 0803-5253
VL - 112
SP - 1185
EP - 1189
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 6
ER -