Abstract
Juvenile turbot (Scophthalmus maximus) were injected intraperitoneally with either corn oil or 5 mg/kg benzo[a]pyrene (BaP) dissolved in corn oil and sampled I and 3 days after injection. After 1 day, no elevation of 7-ethoxyresorufin O-deethylase (EROD) activity was observed, however bile metabolites (BaP-7,8 dihydrodiol representing 70% of the total metabolites) and a single hepatic DNA adduct spot (0.47 adducts/10(8) nucleotides) identified by 32P-postlabelling were formed. No BaP metabolites or DNA adducts were observed in either control or carrier control fish. Fish sampled after 3 days reported 5-fold higher (P
| Original language | English |
|---|---|
| Pages (from-to) | 511-5 |
| Number of pages | 5 |
| Journal | MARINE ENVIRONMENTAL RESEARCH |
| Volume | 54 |
| Issue number | 3-5 |
| Publication status | Published - 2002 |
Keywords
- Animals
- Benzo(a)pyrene
- Cytochrome P-450 CYP1A1
- DNA Adducts
- DNA Damage
- Enzyme Induction
- Flatfishes
- Injections, Intraperitoneal
- Oxidative Stress
- Water Pollutants, Chemical