TY - JOUR
T1 - COVID-19 Risk Factors for Cancer Patients
T2 - A First Report with Comparator Data from COVID-19 Negative Cancer Patients
AU - Russell, Beth
AU - Moss, Charlotte L
AU - Palmer, Kieran
AU - Sylva, Rushan
AU - D'Souza, Andrea
AU - Wylie, Harriet
AU - Haire, Anna
AU - Cahill, Fidelma
AU - Steel, Renee
AU - Hoyes, Angela
AU - Wilson, Isabelle
AU - Macneil, Alyson
AU - Shifa, Belul
AU - Monroy-Iglesias, Maria J
AU - Papa, Sophie
AU - Irshad, Sheeba
AU - Ross, Paul
AU - Spicer, James
AU - Kordasti, Shahram
AU - Crawley, Danielle
AU - Zaki, Kamarul
AU - Sita-Lumsden, Ailsa
AU - Josephs, Debra
AU - Enting, Deborah
AU - Swampillai, Angela
AU - Sawyer, Elinor
AU - Fields, Paul
AU - Wrench, David
AU - Rigg, Anne
AU - Sullivan, Richard
AU - Van Hemelrijck, Mieke
AU - Dolly, Saoirse
N1 - Funding Information:
This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) based at Guy?s and St Thomas? NHS Foundation Trust and King?s College London (IS?BRC?1215?20006). The authors are solely responsible for study design, data collection, analysis, decision to publish, and preparation of the manuscript. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. We also acknowledge support from Cancer Research UK King?s Health Partners Centre at King?s College London and Guy?s and St Thomas? NHS Foundation Trust Charity Cancer Fund.
Funding Information:
Funding: This research was supported by the National Institute for Health Research (NIHR) Bio‐ medical Research Centre (BRC) based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London (IS‐BRC‐1215‐20006). The authors are solely responsible for study design, data col‐ lection, analysis, decision to publish, and preparation of the manuscript. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. We also acknowledge support from Cancer Research UK King’s Health Partners Centre at King’s College London and Guy’s and St Thomas’ NHS Foundation Trust Charity Cancer Fund.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/19
Y1 - 2021/5/19
N2 - Very few studies investigating COVID-19 in cancer patients have included cancer patients as controls. We aimed to identify factors associated with the risk of testing positive for SARS CoV2 infection in a cohort of cancer patients. We analyzed data from all cancer patients swabbed for COVID-19 between 1st March and 31st July 2020 at Guy's Cancer Centre. We conducted logistic regression analyses to identify which factors were associated with a positive COVID-19 test. Results: Of the 2152 patients tested for COVID-19, 190 (9%) tested positive. Male sex, black ethnicity, and hematological cancer type were positively associated with risk of COVID-19 (OR = 1.85, 95%CI:1.37-2.51; OR = 1.93, 95%CI:1.31-2.84; OR = 2.29, 95%CI:1.45-3.62, respectively) as compared to females, white ethnicity, or solid cancer type, respectively. Male, Asian ethnicity, and hematological cancer type were associated with an increased risk of severe COVID-19 (OR = 3.12, 95%CI:1.58-6.14; OR = 2.97, 95%CI:1.00-8.93; OR = 2.43, 95%CI:1.00-5.90, respectively). This study is one of the first to compare the risk of COVID-19 incidence and severity in cancer patients when including cancer patients as controls. Results from this study have echoed those of previous reports, that patients who are male, of black or Asian ethnicity, or with a hematological malignancy are at an increased risk of COVID-19.
AB - Very few studies investigating COVID-19 in cancer patients have included cancer patients as controls. We aimed to identify factors associated with the risk of testing positive for SARS CoV2 infection in a cohort of cancer patients. We analyzed data from all cancer patients swabbed for COVID-19 between 1st March and 31st July 2020 at Guy's Cancer Centre. We conducted logistic regression analyses to identify which factors were associated with a positive COVID-19 test. Results: Of the 2152 patients tested for COVID-19, 190 (9%) tested positive. Male sex, black ethnicity, and hematological cancer type were positively associated with risk of COVID-19 (OR = 1.85, 95%CI:1.37-2.51; OR = 1.93, 95%CI:1.31-2.84; OR = 2.29, 95%CI:1.45-3.62, respectively) as compared to females, white ethnicity, or solid cancer type, respectively. Male, Asian ethnicity, and hematological cancer type were associated with an increased risk of severe COVID-19 (OR = 3.12, 95%CI:1.58-6.14; OR = 2.97, 95%CI:1.00-8.93; OR = 2.43, 95%CI:1.00-5.90, respectively). This study is one of the first to compare the risk of COVID-19 incidence and severity in cancer patients when including cancer patients as controls. Results from this study have echoed those of previous reports, that patients who are male, of black or Asian ethnicity, or with a hematological malignancy are at an increased risk of COVID-19.
KW - Cancer
KW - COVID‐19
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85106203457&partnerID=8YFLogxK
U2 - 10.3390/cancers13102479
DO - 10.3390/cancers13102479
M3 - Article
C2 - 34069565
AN - SCOPUS:85106203457
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 10
M1 - 2479
ER -
