Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

Julia Mantaj; S M Abdur Rahman; Bishwajit Bokshi; Choudhury Hasan; Paul Jackson; Richard Parsons; Khondaker Rahman

doi:10.1039/c5ob00052a

Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

Julia Mantaj, S M Abdur Rahman, Bishwajit Bokshi, Choudhury Hasan, Paul Jackson, Richard Parsons, Khondaker Rahman

Institute of Pharmaceutical Science

University of Dhaka

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Crispene E, a new clerodane-type diterpene, inhibited STAT3 dimerization in a cell-free fluorescent polarisation assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes cyclin D1, Fascin and bcl-2. Molecular docking studies suggest the molecule inhibits STAT3 by interacting with its SH2 domain. The compound has been isolated from Tinospora crispa and characterized using standard spectroscopic techniques.

Original language	English
Pages (from-to)	3882-3886
Number of pages	5
Journal	ORGANIC AND BIOMOLECULAR CHEMISTRY
Volume	13
Issue number	13
DOIs	https://doi.org/10.1039/c5ob00052a
Publication status	Published - 7 Apr 2015

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title = "Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells",

abstract = "Crispene E, a new clerodane-type diterpene, inhibited STAT3 dimerization in a cell-free fluorescent polarisation assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes cyclin D1, Fascin and bcl-2. Molecular docking studies suggest the molecule inhibits STAT3 by interacting with its SH2 domain. The compound has been isolated from Tinospora crispa and characterized using standard spectroscopic techniques. ",

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AU - Mantaj, Julia

AU - Rahman, S M Abdur

AU - Bokshi, Bishwajit

AU - Hasan, Choudhury

AU - Jackson, Paul

AU - Parsons, Richard

AU - Rahman, Khondaker

PY - 2015/4/7

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AB - Crispene E, a new clerodane-type diterpene, inhibited STAT3 dimerization in a cell-free fluorescent polarisation assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes cyclin D1, Fascin and bcl-2. Molecular docking studies suggest the molecule inhibits STAT3 by interacting with its SH2 domain. The compound has been isolated from Tinospora crispa and characterized using standard spectroscopic techniques.

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Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

Abstract

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