Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis

Andrea Bacigalupo*, Gerard Socie, Rose Marie Hamladji, Mahmoud Aljurf, Alexei Maschan, Slawomira Kyrcz-Krzemien, Alicja Cybicka, Henrik Sengelov, Ali Unal, Dietrich Beelen, Anna Locasciulli, Carlo Dufour, Jakob R. Passweg, Rosi Oneto, Alessio Signori, Judith C W Marsh

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    143 Citations (Scopus)

    Abstract

    We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P

    Original languageEnglish
    Pages (from-to)696-702
    Number of pages7
    JournalHaematologica
    Volume100
    Issue number5
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Dive into the research topics of 'Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis'. Together they form a unique fingerprint.

    Cite this

    Bacigalupo, A., Socie, G., Hamladji, R. M., Aljurf, M., Maschan, A., Kyrcz-Krzemien, S., Cybicka, A., Sengelov, H., Unal, A., Beelen, D., Locasciulli, A., Dufour, C., Passweg, J. R., Oneto, R., Signori, A., & Marsh, J. C. W. (2015). Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis. Haematologica, 100(5), 696-702. https://doi.org/10.3324/haematol.2014.115345