Bacigalupo, A., Socie, G., Hamladji, R. M., Aljurf, M., Maschan, A., Kyrcz-Krzemien, S., Cybicka, A., Sengelov, H., Unal, A., Beelen, D., Locasciulli, A., Dufour, C., Passweg, J. R., Oneto, R., Signori, A., & Marsh, J. C. W. (2015). Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis. Haematologica, 100(5), 696-702. https://doi.org/10.3324/haematol.2014.115345
Bacigalupo, Andrea ; Socie, Gerard ; Hamladji, Rose Marie et al. / Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia : An EBMT analysis. In: Haematologica. 2015 ; Vol. 100, No. 5. pp. 696-702.
@article{48dd9d195379435baa96e983ae8cd124,
title = "Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis",
abstract = "We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P",
author = "Andrea Bacigalupo and Gerard Socie and Hamladji, {Rose Marie} and Mahmoud Aljurf and Alexei Maschan and Slawomira Kyrcz-Krzemien and Alicja Cybicka and Henrik Sengelov and Ali Unal and Dietrich Beelen and Anna Locasciulli and Carlo Dufour and Passweg, {Jakob R.} and Rosi Oneto and Alessio Signori and Marsh, {Judith C W}",
year = "2015",
doi = "10.3324/haematol.2014.115345",
language = "English",
volume = "100",
pages = "696--702",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "5",
}
Bacigalupo, A, Socie, G, Hamladji, RM, Aljurf, M, Maschan, A, Kyrcz-Krzemien, S, Cybicka, A, Sengelov, H, Unal, A, Beelen, D, Locasciulli, A, Dufour, C, Passweg, JR, Oneto, R, Signori, A & Marsh, JCW 2015, 'Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis', Haematologica, vol. 100, no. 5, pp. 696-702. https://doi.org/10.3324/haematol.2014.115345
Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis. / Bacigalupo, Andrea; Socie, Gerard; Hamladji, Rose Marie et al.
In:
Haematologica, Vol. 100, No. 5, 2015, p. 696-702.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia
T2 - An EBMT analysis
AU - Bacigalupo, Andrea
AU - Socie, Gerard
AU - Hamladji, Rose Marie
AU - Aljurf, Mahmoud
AU - Maschan, Alexei
AU - Kyrcz-Krzemien, Slawomira
AU - Cybicka, Alicja
AU - Sengelov, Henrik
AU - Unal, Ali
AU - Beelen, Dietrich
AU - Locasciulli, Anna
AU - Dufour, Carlo
AU - Passweg, Jakob R.
AU - Oneto, Rosi
AU - Signori, Alessio
AU - Marsh, Judith C W
PY - 2015
Y1 - 2015
N2 - We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P
AB - We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P
UR - http://www.scopus.com/inward/record.url?scp=84929151714&partnerID=8YFLogxK
U2 - 10.3324/haematol.2014.115345
DO - 10.3324/haematol.2014.115345
M3 - Article
AN - SCOPUS:84929151714
SN - 0390-6078
VL - 100
SP - 696
EP - 702
JO - Haematologica
JF - Haematologica
IS - 5
ER -
Bacigalupo A, Socie G, Hamladji RM, Aljurf M, Maschan A, Kyrcz-Krzemien S et al. Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis. Haematologica. 2015;100(5):696-702. doi: 10.3324/haematol.2014.115345