Current Status of COVID-19 Therapies and Drug Repositioning Applications

Ozlem Altay; Elyas Mohammadi; Simon Lam; Hasan Turkez; Jan Boren; Jens Nielsen; Mathias Uhlen; Adil Mardinoglu

doi:10.1016/j.isci.2020.101303

Current Status of COVID-19 Therapies and Drug Repositioning Applications

Ozlem Altay, Elyas Mohammadi, Simon Lam, Hasan Turkez, Jan Boren, Jens Nielsen, Mathias Uhlen, Adil Mardinoglu^*

^*Corresponding author for this work

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Review article › peer-review

75 Citations (Scopus)

Abstract

The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.

Original language	English
Article number	101303
Journal	iScience
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.isci.2020.101303
Publication status	Published - 24 Jul 2020

Keywords

Health Sciences
Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.isci.2020.101303

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abstract = "The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.",

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AU - Altay, Ozlem

AU - Mohammadi, Elyas

AU - Lam, Simon

AU - Turkez, Hasan

AU - Boren, Jan

AU - Nielsen, Jens

AU - Uhlen, Mathias

AU - Mardinoglu, Adil

PY - 2020/7/24

Y1 - 2020/7/24

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AB - The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.

KW - Health Sciences

KW - Medicine

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DO - 10.1016/j.isci.2020.101303

M3 - Review article

AN - SCOPUS:85087180423

SN - 2589-0042

VL - 23

JO - iScience

JF - iScience

IS - 7

M1 - 101303

ER -

Current Status of COVID-19 Therapies and Drug Repositioning Applications

Abstract

Keywords

UN SDGs

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