Current Treatment and Immunomodulation Strategies in Acute Myocarditis

Emma Ferone; Amitai Segev; Erika Tempo; Piero Gentile; Ahmed Elsanhoury; Chiara Baggio; Jessica Artico; Prashan Bhatti; Paul Scott; Emanuele Bobbio; Marco Merlo; Pietro Ameri; Gianfranco Sinagra; Carsten Tschöpe; Daniel Bromage; Antonio Cannata

doi:10.1097/FJC.0000000000001542

Current Treatment and Immunomodulation Strategies in Acute Myocarditis

Emma Ferone, Amitai Segev, Erika Tempo, Piero Gentile, Ahmed Elsanhoury, Chiara Baggio, Jessica Artico, Prashan Bhatti, Paul Scott, Emanuele Bobbio, Marco Merlo, Pietro Ameri, Gianfranco Sinagra, Carsten Tschöpe, Daniel Bromage^*, Antonio Cannata

^*Corresponding author for this work

SCMMS Denmark Hill

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Myocarditis is an inflammatory disease of the myocardium characterized by a great heterogeneity of presentation and evolution. Treatment of myocarditis is often supportive, and the evidence for immunosuppression is scarce and debated. Conventional treatment is based on clinical presentation, ranging from conservative to advanced mechanical assist devices. In this setting, immunosuppression and immunomodulation therapies are mostly reserved for patients presenting with major clinical syndromes. In this review, we will summarize the current evidence and strategies for conventional and immunosuppressive treatments for patients presenting with acute myocarditis.

Original language	English
Pages (from-to)	364-376
Number of pages	13
Journal	Journal of Cardiovascular Pharmacology
Volume	83
Issue number	5
DOIs	https://doi.org/10.1097/FJC.0000000000001542
Publication status	Published - 2 May 2024

Keywords

immunosuppression
inflammation
inflammatory disease
myocarditis
steroids
treatment

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Ferone, E., Segev, A., Tempo, E., Gentile, P., Elsanhoury, A., Baggio, C., Artico, J., Bhatti, P., Scott, P., Bobbio, E., Merlo, M., Ameri, P., Sinagra, G., Tschöpe, C., Bromage, D., & Cannata, A. (2024). Current Treatment and Immunomodulation Strategies in Acute Myocarditis. Journal of Cardiovascular Pharmacology, 83(5), 364-376. https://doi.org/10.1097/FJC.0000000000001542

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abstract = "Myocarditis is an inflammatory disease of the myocardium characterized by a great heterogeneity of presentation and evolution. Treatment of myocarditis is often supportive, and the evidence for immunosuppression is scarce and debated. Conventional treatment is based on clinical presentation, ranging from conservative to advanced mechanical assist devices. In this setting, immunosuppression and immunomodulation therapies are mostly reserved for patients presenting with major clinical syndromes. In this review, we will summarize the current evidence and strategies for conventional and immunosuppressive treatments for patients presenting with acute myocarditis.",

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Ferone, E, Segev, A, Tempo, E, Gentile, P, Elsanhoury, A, Baggio, C, Artico, J, Bhatti, P, Scott, P, Bobbio, E, Merlo, M, Ameri, P, Sinagra, G, Tschöpe, C, Bromage, D & Cannata, A 2024, 'Current Treatment and Immunomodulation Strategies in Acute Myocarditis', Journal of Cardiovascular Pharmacology, vol. 83, no. 5, pp. 364-376. https://doi.org/10.1097/FJC.0000000000001542

TY - JOUR

T1 - Current Treatment and Immunomodulation Strategies in Acute Myocarditis

AU - Ferone, Emma

AU - Segev, Amitai

AU - Tempo, Erika

AU - Gentile, Piero

AU - Elsanhoury, Ahmed

AU - Baggio, Chiara

AU - Artico, Jessica

AU - Bhatti, Prashan

AU - Scott, Paul

AU - Bobbio, Emanuele

AU - Merlo, Marco

AU - Ameri, Pietro

AU - Sinagra, Gianfranco

AU - Tschöpe, Carsten

AU - Bromage, Daniel

AU - Cannata, Antonio

PY - 2024/5/2

Y1 - 2024/5/2

N2 - Myocarditis is an inflammatory disease of the myocardium characterized by a great heterogeneity of presentation and evolution. Treatment of myocarditis is often supportive, and the evidence for immunosuppression is scarce and debated. Conventional treatment is based on clinical presentation, ranging from conservative to advanced mechanical assist devices. In this setting, immunosuppression and immunomodulation therapies are mostly reserved for patients presenting with major clinical syndromes. In this review, we will summarize the current evidence and strategies for conventional and immunosuppressive treatments for patients presenting with acute myocarditis.

AB - Myocarditis is an inflammatory disease of the myocardium characterized by a great heterogeneity of presentation and evolution. Treatment of myocarditis is often supportive, and the evidence for immunosuppression is scarce and debated. Conventional treatment is based on clinical presentation, ranging from conservative to advanced mechanical assist devices. In this setting, immunosuppression and immunomodulation therapies are mostly reserved for patients presenting with major clinical syndromes. In this review, we will summarize the current evidence and strategies for conventional and immunosuppressive treatments for patients presenting with acute myocarditis.

KW - immunosuppression

KW - inflammation

KW - inflammatory disease

KW - myocarditis

KW - steroids

KW - treatment

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U2 - 10.1097/FJC.0000000000001542

DO - 10.1097/FJC.0000000000001542

M3 - Review article

C2 - 38335530

AN - SCOPUS:85193024344

SN - 0160-2446

VL - 83

SP - 364

EP - 376

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

IS - 5

ER -

Current Treatment and Immunomodulation Strategies in Acute Myocarditis

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Keywords

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