CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation

Cedric Auffray; Darin K Fogg; Emilie Narni-Mancinelli; Brigitte Senechal; Celine Trouillet; Noah Saederup; Julia Leemput; Karine Bigot; Laura Campisi; Marc Abitbol; Thierry Molina; Israel Charo; David A Hume; Ana Cumano; Gregoire Lauvau; Frederic Geissmann

doi:10.1084/jem.20081385

CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation

Cedric Auffray, Darin K Fogg, Emilie Narni-Mancinelli, Brigitte Senechal, Celine Trouillet, Noah Saederup, Julia Leemput, Karine Bigot, Laura Campisi, Marc Abitbol, Thierry Molina, Israel Charo, David A Hume, Ana Cumano, Gregoire Lauvau, Frederic Geissmann

Inflammation Biology

Research output: Contribution to journal › Article › peer-review

333 Citations (Scopus)

Abstract

CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

Original language	English
Pages (from-to)	595-606
Number of pages	12
Journal	Journal of Experimental Medicine
Volume	206
Issue number	3
DOIs	https://doi.org/10.1084/jem.20081385
Publication status	Published - 16 Mar 2009

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Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., Molina, T., Charo, I., Hume, D. A., Cumano, A., Lauvau, G., & Geissmann, F. (2009). CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation. Journal of Experimental Medicine, 206(3), 595-606. https://doi.org/10.1084/jem.20081385

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title = "CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation",

abstract = "CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.",

author = "Cedric Auffray and Fogg, {Darin K} and Emilie Narni-Mancinelli and Brigitte Senechal and Celine Trouillet and Noah Saederup and Julia Leemput and Karine Bigot and Laura Campisi and Marc Abitbol and Thierry Molina and Israel Charo and Hume, {David A} and Ana Cumano and Gregoire Lauvau and Frederic Geissmann",

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Auffray, C, Fogg, DK, Narni-Mancinelli, E, Senechal, B, Trouillet, C, Saederup, N, Leemput, J, Bigot, K, Campisi, L, Abitbol, M, Molina, T, Charo, I, Hume, DA, Cumano, A, Lauvau, G & Geissmann, F 2009, 'CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation', Journal of Experimental Medicine, vol. 206, no. 3, pp. 595-606. https://doi.org/10.1084/jem.20081385

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T1 - CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation

AU - Auffray, Cedric

AU - Fogg, Darin K

AU - Narni-Mancinelli, Emilie

AU - Senechal, Brigitte

AU - Trouillet, Celine

AU - Saederup, Noah

AU - Leemput, Julia

AU - Bigot, Karine

AU - Campisi, Laura

AU - Abitbol, Marc

AU - Molina, Thierry

AU - Charo, Israel

AU - Hume, David A

AU - Cumano, Ana

AU - Lauvau, Gregoire

AU - Geissmann, Frederic

PY - 2009/3/16

Y1 - 2009/3/16

N2 - CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

AB - CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

U2 - 10.1084/jem.20081385

DO - 10.1084/jem.20081385

M3 - Article

C2 - 19273628

VL - 206

SP - 595

EP - 606

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 3

ER -

CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation

Abstract

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