Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-beta Production

Emma H. Gray; Kurt J. De Vos; Colin Dingwall; Michael S. Perkinton; Christopher C. J. Miller

doi:10.3233/JAD-2010-100717

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-beta Production

Emma H. Gray, Kurt J. De Vos, Colin Dingwall, Michael S. Perkinton, Christopher C. J. Miller

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The copper chaperone for superoxide dismutase (CCS) binds to both the beta-site A beta PP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11 alpha. BACE1 initiates A beta PP processing to produce the amyloid-beta (A beta) peptide deposited in the brains of Alzheimer's disease patients. X11 alpha also interacts directly with A beta PP to inhibit A beta production. However, whether CCS affects A beta PP processing and A beta production is not known. Here we show that loss of CCS increases A beta production in both CCS knockout neurons and CCS siRNA- treated SHSY5Y cells and that this involves increased A beta PP processing at the BACE1 site.

Original language	English
Pages (from-to)	1101 - 1105
Number of pages	5
Journal	JOURNAL OF ALZHEIMERS DISEASE
Volume	21
Issue number	4
DOIs	https://doi.org/10.3233/JAD-2010-100717
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3233/JAD-2010-100717

Cite this

@article{c77f86803cdb4426a654d3fc47c5320c,

title = "Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-beta Production",

abstract = "The copper chaperone for superoxide dismutase (CCS) binds to both the beta-site A beta PP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11 alpha. BACE1 initiates A beta PP processing to produce the amyloid-beta (A beta) peptide deposited in the brains of Alzheimer's disease patients. X11 alpha also interacts directly with A beta PP to inhibit A beta production. However, whether CCS affects A beta PP processing and A beta production is not known. Here we show that loss of CCS increases A beta production in both CCS knockout neurons and CCS siRNA- treated SHSY5Y cells and that this involves increased A beta PP processing at the BACE1 site.",

author = "Gray, {Emma H.} and {De Vos}, {Kurt J.} and Colin Dingwall and Perkinton, {Michael S.} and Miller, {Christopher C. J.}",

year = "2010",

doi = "10.3233/JAD-2010-100717",

language = "English",

volume = "21",

pages = "1101 -- 1105",

journal = "JOURNAL OF ALZHEIMERS DISEASE",

publisher = "IOS Press BV",

number = "4",

}

TY - JOUR

T1 - Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-beta Production

AU - Gray, Emma H.

AU - De Vos, Kurt J.

AU - Dingwall, Colin

AU - Perkinton, Michael S.

AU - Miller, Christopher C. J.

PY - 2010

Y1 - 2010

N2 - The copper chaperone for superoxide dismutase (CCS) binds to both the beta-site A beta PP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11 alpha. BACE1 initiates A beta PP processing to produce the amyloid-beta (A beta) peptide deposited in the brains of Alzheimer's disease patients. X11 alpha also interacts directly with A beta PP to inhibit A beta production. However, whether CCS affects A beta PP processing and A beta production is not known. Here we show that loss of CCS increases A beta production in both CCS knockout neurons and CCS siRNA- treated SHSY5Y cells and that this involves increased A beta PP processing at the BACE1 site.

AB - The copper chaperone for superoxide dismutase (CCS) binds to both the beta-site A beta PP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11 alpha. BACE1 initiates A beta PP processing to produce the amyloid-beta (A beta) peptide deposited in the brains of Alzheimer's disease patients. X11 alpha also interacts directly with A beta PP to inhibit A beta production. However, whether CCS affects A beta PP processing and A beta production is not known. Here we show that loss of CCS increases A beta production in both CCS knockout neurons and CCS siRNA- treated SHSY5Y cells and that this involves increased A beta PP processing at the BACE1 site.

U2 - 10.3233/JAD-2010-100717

DO - 10.3233/JAD-2010-100717

M3 - Article

VL - 21

SP - 1101

EP - 1105

JO - JOURNAL OF ALZHEIMERS DISEASE

JF - JOURNAL OF ALZHEIMERS DISEASE

IS - 4

ER -

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-beta Production

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this