TY - JOUR
T1 - Deletion variant of α2b-adrenergic receptor gene moderates the effect of COMT val158met polymorphism on episodic memory performance
AU - Gibbs, A.A.
AU - Naudts, K.H.
AU - Azevedo, R.T.
AU - David, A.S.
PY - 2010/4
Y1 - 2010/4
N2 - The COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
AB - The COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
U2 - 10.1016/j.euroneuro.2009.12.007
DO - 10.1016/j.euroneuro.2009.12.007
M3 - Article
SN - 1873-7862
VL - 20
SP - 272
EP - 275
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 4
ER -
