Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception

B M Brady; M Walton; N Hollow; A T Kicman; D T Baird; R A Anderson

doi:10.1093/humrep/deh491

Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception

B M Brady, M Walton, N Hollow, A T Kicman, D T Baird, R A Anderson

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Background: Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period of 48 weeks. Methods: Fifteen healthy men received three s.c. 68 mg etonogestrel implants. Testosterone pellets (400 mg) were administered at 12 weekly intervals. Results: Nine men completed 48 weeks of treatment. Four subjects chose to discontinue after 6 months, one man withdrew from the study early for personal reasons and one was withdrawn due to illness. Sperm concentrations of

Original language	English
Pages (from-to)	2658 - 2667
Number of pages	10
Journal	Human Reproduction
Volume	19
Issue number	11
DOIs	https://doi.org/10.1093/humrep/deh491
Publication status	Published - Nov 2004

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abstract = "Background: Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period of 48 weeks. Methods: Fifteen healthy men received three s.c. 68 mg etonogestrel implants. Testosterone pellets (400 mg) were administered at 12 weekly intervals. Results: Nine men completed 48 weeks of treatment. Four subjects chose to discontinue after 6 months, one man withdrew from the study early for personal reasons and one was withdrawn due to illness. Sperm concentrations of ",

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AU - Walton, M

AU - Hollow, N

AU - Kicman, A T

AU - Baird, D T

AU - Anderson, R A

PY - 2004/11

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N2 - Background: Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period of 48 weeks. Methods: Fifteen healthy men received three s.c. 68 mg etonogestrel implants. Testosterone pellets (400 mg) were administered at 12 weekly intervals. Results: Nine men completed 48 weeks of treatment. Four subjects chose to discontinue after 6 months, one man withdrew from the study early for personal reasons and one was withdrawn due to illness. Sperm concentrations of

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Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception

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