TY - JOUR
T1 - Design and Implementation of Multicenter Pediatric and Congenital Studies with Cardiovascular Magnetic Resonance
T2 - Big Data in Smaller Bodies
AU - DiLorenzo, Michael P
AU - Lee, Simon
AU - Rathod, Rahul H
AU - Raimondi, Francesca
AU - Farooqi, Kanwal M
AU - Jain, Supriya S
AU - Samyn, Margaret M
AU - Johnson, Tiffanie R
AU - Olivieri, Laura J
AU - Fogel, Mark A
AU - Lai, Wyman W
AU - Renella, Pierangelo
AU - Powell, Andrew J
AU - Buddhe, Sujatha
AU - Stafford, Caitlin
AU - Johnson, Jason N
AU - Helbing, Willem A
AU - Pushparajah, Kuberan
AU - Voges, Inga
AU - Muthurangu, Vivek
AU - Miles, Kimberley G
AU - Greil, Gerald
AU - McMahon, Colin J
AU - Slesnick, Timothy C
AU - Fonseca, Brian M
AU - Morris, Shaine A
AU - Soslow, Jonathan H
AU - Grosse-Wortmann, Lars
AU - Beroukhim, Rebecca S
AU - Grotenhuis, Heynric B
N1 - Funding Information:
We would like to thank all the study site investigators from PCHD institutions that allowed for the advancement of multicenter research efforts, and the Pediatric and Congenital Heart Disease Section of SCMR for their support for this manuscript. Not applicable. There are no conflicts of interest or industry support directly related to this publication. Michael DiLorenzo reports a relationship with GE Healthcare that includes: funding grants. Mark Fogel reports a relationship with Rocket Pharmaceuticals Inc that includes: consulting or advisory. Mark Fogel reports a relationship with CMP Pharma that includes: funding grants. Andrew Powell reports a relationship with Siemens Medical Solutions USA Inc that includes: consulting or advisory. Shaine Morris reports a relationship with Aytu BioPharma Inc that includes: non-financial support. Kanwal Farooqi reports a relationship with Bristol-Myers Squibb Foundation that includes: funding grants. Jonathan Soslow reports a relationship with Pfizer Inc that includes: consulting or advisory. Jonathan Soslow reports a relationship with Sarepta Therapeutics Inc that includes: consulting or advisory. Jonathan Soslow reports a relationship with Immunoforge that includes: consulting or advisory. Heynric Grotenhuis serves as an associate editor for JCMR. Mark Fogel and Andrew Powell serve as members of the editorial board for JCMR. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Publisher Copyright:
© 2024 The Author(s)
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.
AB - Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.
UR - http://www.scopus.com/inward/record.url?scp=85189463377&partnerID=8YFLogxK
U2 - 10.1016/j.jocmr.2024.101041
DO - 10.1016/j.jocmr.2024.101041
M3 - Review article
C2 - 38527706
SN - 1097-6647
VL - 26
SP - 101041
JO - Journal of Cardiovascular Magnetic Resonance
JF - Journal of Cardiovascular Magnetic Resonance
IS - 1
M1 - 101041
ER -