Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine-Poly(N-methylpyrrole) Conjugates

Geoff Wells; Christopher R. H. Martin; Philip W. Howard; Zara A. Sands; Charles A. Laughton; Arnaud Tiberghien; Chi Kit Woo; Luke A. Masterson; Marissa J. Stephenson; John A. Hartley; Terence C. Jenkins; Steven D. Shnyder; Paul M. Loadman; Michael J. Waring; David E. Thurston

doi:10.1021/jm051199z

Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine-Poly(N-methylpyrrole) Conjugates

Geoff Wells, Christopher R. H. Martin, Philip W. Howard, Zara A. Sands, Charles A. Laughton, Arnaud Tiberghien, Chi Kit Woo, Luke A. Masterson, Marissa J. Stephenson, John A. Hartley, Terence C. Jenkins, Steven D. Shnyder, Paul M. Loadman, Michael J. Waring, David E. Thurston

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Original language	English
Pages (from-to)	5442-5461
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	18
DOIs	https://doi.org/10.1021/jm051199z
Publication status	Published - 1 Sept 2006

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10.1021/jm051199z

Cite this

Wells, G., Martin, C. R. H., Howard, P. W., Sands, Z. A., Laughton, C. A., Tiberghien, A., Woo, C. K., Masterson, L. A., Stephenson, M. J., Hartley, J. A., Jenkins, T. C., Shnyder, S. D., Loadman, P. M., Waring, M. J., & Thurston, D. E. (2006). Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine-Poly(N-methylpyrrole) Conjugates. Journal of Medicinal Chemistry, 49(18), 5442-5461. https://doi.org/10.1021/jm051199z

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title = "Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine-Poly(N-methylpyrrole) Conjugates",

author = "Geoff Wells and Martin, {Christopher R. H.} and Howard, {Philip W.} and Sands, {Zara A.} and Laughton, {Charles A.} and Arnaud Tiberghien and Woo, {Chi Kit} and Masterson, {Luke A.} and Stephenson, {Marissa J.} and Hartley, {John A.} and Jenkins, {Terence C.} and Shnyder, {Steven D.} and Loadman, {Paul M.} and Waring, {Michael J.} and Thurston, {David E.}",

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Wells, G, Martin, CRH, Howard, PW, Sands, ZA, Laughton, CA, Tiberghien, A, Woo, CK, Masterson, LA, Stephenson, MJ, Hartley, JA, Jenkins, TC, Shnyder, SD, Loadman, PM, Waring, MJ & Thurston, DE 2006, 'Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine-Poly(N-methylpyrrole) Conjugates', Journal of Medicinal Chemistry, vol. 49, no. 18, pp. 5442-5461. https://doi.org/10.1021/jm051199z

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T1 - Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine-Poly(N-methylpyrrole) Conjugates

AU - Wells, Geoff

AU - Martin, Christopher R. H.

AU - Howard, Philip W.

AU - Sands, Zara A.

AU - Laughton, Charles A.

AU - Tiberghien, Arnaud

AU - Woo, Chi Kit

AU - Masterson, Luke A.

AU - Stephenson, Marissa J.

AU - Hartley, John A.

AU - Jenkins, Terence C.

AU - Shnyder, Steven D.

AU - Loadman, Paul M.

AU - Waring, Michael J.

AU - Thurston, David E.

PY - 2006/9/1

Y1 - 2006/9/1

U2 - 10.1021/jm051199z

DO - 10.1021/jm051199z

M3 - Article

SN - 0022-2623

VL - 49

SP - 5442

EP - 5461

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 18

ER -