Detection of CD59 using flow cytometry

Martin Kolev

doi:10.1007/978-1-62703-724-2_28

Detection of CD59 using flow cytometry

Martin Kolev^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

CD59 is the single regulator of the terminal complement pathway. It has been implicated in disease such as Paroxysmal nocturnal hemoglobinuria (PMH) and cancer. Expression of CD59 protects normal and malignant cells from the cytotoxic potential of the complement system. Here we describe a method, which allows for studying its expression on the surface of cells.

Original language	English
Title of host publication	The Complement System: Methods and Protocols
Publisher	Humana Press Inc
Pages	341-346
Number of pages	6
Volume	1100
ISBN (Print)	9781627037235
DOIs	https://doi.org/10.1007/978-1-62703-724-2_28
Publication status	Published - 2014

Publication series

Name	Methods in Molecular Biology
Volume	1100
ISSN (Print)	10643745

Keywords

Antibodies
CD59
Complement protection
Flow cytometry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-62703-724-2_28

Cite this

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title = "Detection of CD59 using flow cytometry",

abstract = "CD59 is the single regulator of the terminal complement pathway. It has been implicated in disease such as Paroxysmal nocturnal hemoglobinuria (PMH) and cancer. Expression of CD59 protects normal and malignant cells from the cytotoxic potential of the complement system. Here we describe a method, which allows for studying its expression on the surface of cells.",

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AB - CD59 is the single regulator of the terminal complement pathway. It has been implicated in disease such as Paroxysmal nocturnal hemoglobinuria (PMH) and cancer. Expression of CD59 protects normal and malignant cells from the cytotoxic potential of the complement system. Here we describe a method, which allows for studying its expression on the surface of cells.

KW - Antibodies

KW - CD59

KW - Complement protection

KW - Flow cytometry

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DO - 10.1007/978-1-62703-724-2_28

M3 - Chapter

AN - SCOPUS:84934438034

SN - 9781627037235

VL - 1100

T3 - Methods in Molecular Biology

SP - 341

EP - 346

BT - The Complement System: Methods and Protocols

PB - Humana Press Inc

ER -

Detection of CD59 using flow cytometry

Abstract

Publication series

Keywords

UN SDGs

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