Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science

Kenneth D Skeldon; Graham M Gibson; Cathy A Wyse; Lesley C McMillan; Steve D Monk; Chris Longbottom; Miles J Padgett; Christopher Longbottom

Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science

Kenneth D Skeldon, Graham M Gibson, Cathy A Wyse, Lesley C McMillan, Steve D Monk, Chris Longbottom, Miles J Padgett, Christopher Longbottom

Centre for Dental Innovation & Translation

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity > or = 70 ppt and response time from > or = 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential.

Original language	English
Pages (from-to)	4712-21
Number of pages	10
Journal	Applied Optics
Volume	44
Issue number	22
Publication status	Published - 1 Aug 2005

Keywords

Animals
Biological Science Disciplines
Breath Tests
Equipment Design
Equipment Failure Analysis
Ethane
Humans
Image Enhancement
Image Interpretation, Computer-Assisted
Microchemistry
Online Systems
Pattern Recognition, Automated
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry, Infrared

Cite this

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title = "Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science",

abstract = "We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity > or = 70 ppt and response time from > or = 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential.",

keywords = "Animals, Biological Science Disciplines, Breath Tests, Equipment Design, Equipment Failure Analysis, Ethane, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Microchemistry, Online Systems, Pattern Recognition, Automated, Pilot Projects, Reproducibility of Results, Sensitivity and Specificity, Spectrophotometry, Infrared",

author = "Skeldon, {Kenneth D} and Gibson, {Graham M} and Wyse, {Cathy A} and McMillan, {Lesley C} and Monk, {Steve D} and Chris Longbottom and Padgett, {Miles J} and Christopher Longbottom",

year = "2005",

month = aug,

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language = "English",

volume = "44",

pages = "4712--21",

journal = "Applied Optics",

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publisher = "The Optical Society",

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T1 - Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science

AU - Skeldon, Kenneth D

AU - Gibson, Graham M

AU - Wyse, Cathy A

AU - McMillan, Lesley C

AU - Monk, Steve D

AU - Longbottom, Chris

AU - Padgett, Miles J

AU - Longbottom, Christopher

PY - 2005/8/1

Y1 - 2005/8/1

N2 - We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity > or = 70 ppt and response time from > or = 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential.

AB - We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity > or = 70 ppt and response time from > or = 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential.

KW - Animals

KW - Biological Science Disciplines

KW - Breath Tests

KW - Equipment Design

KW - Equipment Failure Analysis

KW - Ethane

KW - Humans

KW - Image Enhancement

KW - Image Interpretation, Computer-Assisted

KW - Microchemistry

KW - Online Systems

KW - Pattern Recognition, Automated

KW - Pilot Projects

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Spectrophotometry, Infrared

M3 - Article

C2 - 16075884

SN - 0003-6935

VL - 44

SP - 4712

EP - 4721

JO - Applied Optics

JF - Applied Optics

IS - 22

ER -

Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science

Abstract

Keywords

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