Diagnosis of bacteriuria by detection of volatile organic compounds in urine using an automated headspace analyzer with multiple conducting polymer sensors

S Aathithan, J C Plant, A N Chaudry, G L French

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

The Osmetech Microbial Analyzer (OMA) is an automated headspace analyzer fitted with a novel detector system consisting of an array of polymer sensors, each of which responds to different volatile organic compounds. The system can be used for screening clinical urine specimens for significant bacteriuria by sampling urine headspace and subjecting the output of the multiple-detector response to principal component analysis. The OMA readily distinguished artificially infected urine samples from sterile controls. The OMA was when used to analyze 534 unselected clinical urine specimens, of which 21.5% had significant bacteriuria (containing > 10(5) CFU of bacteria/ml), The sensitivity and specificity of the OMA compared with conventional culture were 83.5 and 87.6%, respectively. The OMA is a promising automated system for the rapid routine screening of urine specimens, and further clinical trials are in progress.
Original languageEnglish
Pages (from-to)2590 - 2593
Number of pages4
JournalJournal of Clinical Microbiology
Volume39
Issue number7
DOIs
Publication statusPublished - 2001

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