TY - JOUR
T1 - Differential expression of MicroRNAs in Alzheimer’s disease
T2 - a systematic review and meta-analysis
AU - Yoon, Sojung
AU - Kim, Sung Eun
AU - Ko, Younhee
AU - Jeong, Gwang Hun
AU - Lee, Keum Hwa
AU - Lee, Jinhee
AU - Solmi, Marco
AU - Jacob, Louis
AU - Smith, Lee
AU - Stickley, Andrew
AU - Carvalho, Andre F.
AU - Dragioti, Elena
AU - Kronbichler, Andreas
AU - Koyanagi, Ai
AU - Hong, Sung Hwi
AU - Thompson, Trevor
AU - Oh, Hans
AU - Salazar de Pablo, Gonzalo
AU - Radua, Joaquim
AU - Shin, Jae Il
AU - Fusar-Poli, Paolo
N1 - Funding Information:
This paper demonstrates independent research and all authors are acknowledged for their contributions to this study.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/5
Y1 - 2022/5
N2 - Alzheimer’s disease (AD) results in progressive cognitive decline owing to the accumulation of amyloid plaques and hyperphosphorylated tau. MicroRNAs (miRNAs) have attracted attention as a putative diagnostic and therapeutic target for neurodegenerative diseases. However, existing meta-analyses on AD and its association with miRNAs have produced inconsistent results. The primary objective of this study is to evaluate the magnitude and consistency of differences in miRNA levels between AD patients, mild cognitive impairment (MCI) patients and healthy controls (HC). Articles investigating miRNA levels in blood, brain tissue, or cerebrospinal fluid (CSF) of AD and MCI patients versus HC were systematically searched in PubMed/Medline from inception to February 16th, 2021. Fixed- and random-effects meta-analyses were complemented with the I2 statistic to measure the heterogeneity, assessment of publication bias, sensitivity subgroup analyses (AD severity, brain region, post-mortem versus ante-mortem specimen for CSF and type of analysis used to quantify miRNA) and functional enrichment pathway analysis. Of the 1512 miRNAs included in 61 articles, 425 meta-analyses were performed on 334 miRNAs. Fifty-six miRNAs were significantly upregulated (n = 40) or downregulated (n = 16) in AD versus HC and all five miRNAs were significantly upregulated in MCI versus HC. Functional enrichment analysis confirmed that pathways related to apoptosis, immune response and inflammation were statistically enriched with upregulated pathways in participants with AD relative to HC. This study confirms that miRNAs’ expression is altered in AD and MCI compared to HC. These findings open new diagnostic and therapeutic perspectives for this disorder.
AB - Alzheimer’s disease (AD) results in progressive cognitive decline owing to the accumulation of amyloid plaques and hyperphosphorylated tau. MicroRNAs (miRNAs) have attracted attention as a putative diagnostic and therapeutic target for neurodegenerative diseases. However, existing meta-analyses on AD and its association with miRNAs have produced inconsistent results. The primary objective of this study is to evaluate the magnitude and consistency of differences in miRNA levels between AD patients, mild cognitive impairment (MCI) patients and healthy controls (HC). Articles investigating miRNA levels in blood, brain tissue, or cerebrospinal fluid (CSF) of AD and MCI patients versus HC were systematically searched in PubMed/Medline from inception to February 16th, 2021. Fixed- and random-effects meta-analyses were complemented with the I2 statistic to measure the heterogeneity, assessment of publication bias, sensitivity subgroup analyses (AD severity, brain region, post-mortem versus ante-mortem specimen for CSF and type of analysis used to quantify miRNA) and functional enrichment pathway analysis. Of the 1512 miRNAs included in 61 articles, 425 meta-analyses were performed on 334 miRNAs. Fifty-six miRNAs were significantly upregulated (n = 40) or downregulated (n = 16) in AD versus HC and all five miRNAs were significantly upregulated in MCI versus HC. Functional enrichment analysis confirmed that pathways related to apoptosis, immune response and inflammation were statistically enriched with upregulated pathways in participants with AD relative to HC. This study confirms that miRNAs’ expression is altered in AD and MCI compared to HC. These findings open new diagnostic and therapeutic perspectives for this disorder.
UR - http://www.scopus.com/inward/record.url?scp=85126057327&partnerID=8YFLogxK
U2 - 10.1038/s41380-022-01476-z
DO - 10.1038/s41380-022-01476-z
M3 - Review article
C2 - 35264731
AN - SCOPUS:85126057327
SN - 1359-4184
VL - 27
SP - 2405
EP - 2413
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 5
ER -
