Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents complexes as anti-cancer stem cell agents†

David O. Abe; Arvin Eskandari; Kogularamanan Suntharalingam

doi:10.1039/c8dt03448f

Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents complexes as anti-cancer stem cell agents†

David O. Abe, Arvin Eskandari, Kogularamanan Suntharalingam^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We report a novel series of cobalt(iii)-polypridyl complexes, 4-6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC₅₀ = 2.1 ± 0.1 μM) over bulk cancer (IC₅₀ = 3.9 ± 0.2 μM) and normal cells (IC₅₀ = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

Original language	English
Pages (from-to)	13761-13765
Number of pages	5
Journal	Dalton Transactions
Volume	47
Issue number	39
DOIs	https://doi.org/10.1039/c8dt03448f
Publication status	Published - 10 Sept 2018

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abstract = "We report a novel series of cobalt(iii)-polypridyl complexes, 4-6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.",

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AU - Suntharalingam, Kogularamanan

PY - 2018/9/10

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N2 - We report a novel series of cobalt(iii)-polypridyl complexes, 4-6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

AB - We report a novel series of cobalt(iii)-polypridyl complexes, 4-6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

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JO - Dalton Transactions

JF - Dalton Transactions

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ER -

Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents complexes as anti-cancer stem cell agents†

Abstract

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