Effect of support matrix on ratio of product to by-product formation in L-phenylacetyl carbinol synthesis

Penka Nikolova; Owen P. Ward

doi:10.1007/BF01022615

Effect of support matrix on ratio of product to by-product formation in L-phenylacetyl carbinol synthesis

Penka Nikolova, Owen P. Ward

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Production of L-phenylacetyl carbinol (PAC) and benzyl alcohol by biotransformation from pyruvate and benzaldehyde substrates was investigated using yeast cells in different polymeric matrices. Highest concentration of PAC was produced by cells immobilised in the hydrophilic matrix, ENT-4000. Highest concentration of the by-product, benzyl alcohol, was produced in the hydrophobic matrix, ENTP-2000. Ratio of PAC to benzyl alcohol ranged from 1∶0.08 for cells entrapped in a poly(propyleneglycol)-containing polymer, PU-3, to 1∶1.8 for cells entrapped in ENTP-2000 polymer.

Original language	English
Article number	N/A
Pages (from-to)	7-10
Number of pages	4
Journal	BIOTECHNOLOGY LETTERS
Volume	16
Issue number	1
DOIs	https://doi.org/10.1007/BF01022615
Publication status	Published - 1 Jan 1994

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title = "Effect of support matrix on ratio of product to by-product formation in L-phenylacetyl carbinol synthesis",

abstract = "Production of L-phenylacetyl carbinol (PAC) and benzyl alcohol by biotransformation from pyruvate and benzaldehyde substrates was investigated using yeast cells in different polymeric matrices. Highest concentration of PAC was produced by cells immobilised in the hydrophilic matrix, ENT-4000. Highest concentration of the by-product, benzyl alcohol, was produced in the hydrophobic matrix, ENTP-2000. Ratio of PAC to benzyl alcohol ranged from 1∶0.08 for cells entrapped in a poly(propyleneglycol)-containing polymer, PU-3, to 1∶1.8 for cells entrapped in ENTP-2000 polymer.",

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year = "1994",

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N2 - Production of L-phenylacetyl carbinol (PAC) and benzyl alcohol by biotransformation from pyruvate and benzaldehyde substrates was investigated using yeast cells in different polymeric matrices. Highest concentration of PAC was produced by cells immobilised in the hydrophilic matrix, ENT-4000. Highest concentration of the by-product, benzyl alcohol, was produced in the hydrophobic matrix, ENTP-2000. Ratio of PAC to benzyl alcohol ranged from 1∶0.08 for cells entrapped in a poly(propyleneglycol)-containing polymer, PU-3, to 1∶1.8 for cells entrapped in ENTP-2000 polymer.

AB - Production of L-phenylacetyl carbinol (PAC) and benzyl alcohol by biotransformation from pyruvate and benzaldehyde substrates was investigated using yeast cells in different polymeric matrices. Highest concentration of PAC was produced by cells immobilised in the hydrophilic matrix, ENT-4000. Highest concentration of the by-product, benzyl alcohol, was produced in the hydrophobic matrix, ENTP-2000. Ratio of PAC to benzyl alcohol ranged from 1∶0.08 for cells entrapped in a poly(propyleneglycol)-containing polymer, PU-3, to 1∶1.8 for cells entrapped in ENTP-2000 polymer.

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ER -

Effect of support matrix on ratio of product to by-product formation in L-phenylacetyl carbinol synthesis

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