Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time

T A Trikalinos; R Churchill; M Ferri; S Leucht; A Tuunainen; K Wahlbeck; J.P.A. Ioannidis; EU-PSI project

doi:10.1016/j.jclinepi.2004.02.018

Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time

T A Trikalinos, R Churchill, M Ferri, S Leucht, A Tuunainen, K Wahlbeck, J.P.A. Ioannidis, EU-PSI project

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Abstract

Background and Objective: Meta-analyses of randomized trials may incorporate new evidence, and estimated treatment effects change over time. We evaluated whether the certainly and estimates of efficacy and tolerability of mental health interventions change over time, as more trials appear on the same topics. Methods: One hundred meta-analyses (1,024 trial entries; 99,303 participants) with an outcome of death, relapse, failure or dropout and with five or more trials published in three or more different years were examined with cumulative meta-analysis and recursive cumulative meta-analysis. Results: Eight meta-analyses reached formal statistical significance (P

Original language	English
Pages (from-to)	1124 - 1130
Number of pages	7
Journal	Journal of Clinical Epidemiology
Volume	57
Issue number	11
DOIs	https://doi.org/10.1016/j.jclinepi.2004.02.018
Publication status	Published - Nov 2004

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10.1016/j.jclinepi.2004.02.018

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abstract = "Background and Objective: Meta-analyses of randomized trials may incorporate new evidence, and estimated treatment effects change over time. We evaluated whether the certainly and estimates of efficacy and tolerability of mental health interventions change over time, as more trials appear on the same topics. Methods: One hundred meta-analyses (1,024 trial entries; 99,303 participants) with an outcome of death, relapse, failure or dropout and with five or more trials published in three or more different years were examined with cumulative meta-analysis and recursive cumulative meta-analysis. Results: Eight meta-analyses reached formal statistical significance (P",

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AU - Trikalinos, T A

AU - Churchill, R

AU - Ferri, M

AU - Leucht, S

AU - Tuunainen, A

AU - Wahlbeck, K

AU - Ioannidis, J.P.A.

AU - EU-PSI project

PY - 2004/11

Y1 - 2004/11

N2 - Background and Objective: Meta-analyses of randomized trials may incorporate new evidence, and estimated treatment effects change over time. We evaluated whether the certainly and estimates of efficacy and tolerability of mental health interventions change over time, as more trials appear on the same topics. Methods: One hundred meta-analyses (1,024 trial entries; 99,303 participants) with an outcome of death, relapse, failure or dropout and with five or more trials published in three or more different years were examined with cumulative meta-analysis and recursive cumulative meta-analysis. Results: Eight meta-analyses reached formal statistical significance (P

AB - Background and Objective: Meta-analyses of randomized trials may incorporate new evidence, and estimated treatment effects change over time. We evaluated whether the certainly and estimates of efficacy and tolerability of mental health interventions change over time, as more trials appear on the same topics. Methods: One hundred meta-analyses (1,024 trial entries; 99,303 participants) with an outcome of death, relapse, failure or dropout and with five or more trials published in three or more different years were examined with cumulative meta-analysis and recursive cumulative meta-analysis. Results: Eight meta-analyses reached formal statistical significance (P

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Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time

Abstract

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