Effects of Buddleja globosa leaf and its constituents relevant to wound healing

A Y Mensah; J Sampson; P J Houghton; P J Hylands; J Westbrook; M Dunn; M A Hughes; G W Cherry

doi:10.1016/S0378-8741(01)00297-5

Effects of Buddleja globosa leaf and its constituents relevant to wound healing

A Y Mensah, J Sampson, P J Houghton, P J Hylands, J Westbrook, M Dunn, M A Hughes, G W Cherry

Research output: Contribution to journal › Article › peer-review

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Abstract

An aqueous extract of Buddleja globosa leaves, used traditionally in Chile for wound healing, was tested for the ability to stimulate growth of fibroblasts in vitro and for antioxidant activity in the same fibroblast cell system challenged with hydrogen peroxide. Low concentrations of the extract gave an increase in fibroblast growth which was not statistically significant but cytotoxicity was observed at concentrations greater than 50 mug/ml. The extract showed strong antioxidant effect and fractionation led to the isolation of three flavonoids and two caffeic acid derivatives, each of which was shown to contribute to the antioxidant effect at concentrations below 10 mug/ml. These activities would accelerate the healing of wounds. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	219 - 226
Number of pages	8
Journal	Journal of Ethnopharmacology
Volume	77
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(01)00297-5
Publication status	Published - 2001

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abstract = "An aqueous extract of Buddleja globosa leaves, used traditionally in Chile for wound healing, was tested for the ability to stimulate growth of fibroblasts in vitro and for antioxidant activity in the same fibroblast cell system challenged with hydrogen peroxide. Low concentrations of the extract gave an increase in fibroblast growth which was not statistically significant but cytotoxicity was observed at concentrations greater than 50 mug/ml. The extract showed strong antioxidant effect and fractionation led to the isolation of three flavonoids and two caffeic acid derivatives, each of which was shown to contribute to the antioxidant effect at concentrations below 10 mug/ml. These activities would accelerate the healing of wounds. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.",

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AU - Mensah, A Y

AU - Sampson, J

AU - Houghton, P J

AU - Hylands, P J

AU - Westbrook, J

AU - Dunn, M

AU - Hughes, M A

AU - Cherry, G W

PY - 2001

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AB - An aqueous extract of Buddleja globosa leaves, used traditionally in Chile for wound healing, was tested for the ability to stimulate growth of fibroblasts in vitro and for antioxidant activity in the same fibroblast cell system challenged with hydrogen peroxide. Low concentrations of the extract gave an increase in fibroblast growth which was not statistically significant but cytotoxicity was observed at concentrations greater than 50 mug/ml. The extract showed strong antioxidant effect and fractionation led to the isolation of three flavonoids and two caffeic acid derivatives, each of which was shown to contribute to the antioxidant effect at concentrations below 10 mug/ml. These activities would accelerate the healing of wounds. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 2-3

ER -

Effects of Buddleja globosa leaf and its constituents relevant to wound healing

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