Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

Mo Li; Keiichiro Suzuki; Jing Qu; Preeti Saini; Ilir Dubova; Fei Yi; Jungmin Lee; Ignacio Sancho-Martinez; Guang-Hui Liu; Juan Carlos Izpisua Belmonte

doi:10.1038/cr.2011.186

Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

Mo Li, Keiichiro Suzuki, Jing Qu, Preeti Saini, Ilir Dubova, Fei Yi, Jungmin Lee, Ignacio Sancho-Martinez, Guang-Hui Liu, Juan Carlos Izpisua Belmonte

Centre for Stem Cells & Regenerative Medicine

Research output: Contribution to journal › Letter › peer-review

62 Citations (Scopus)

Original language	English
Pages (from-to)	1740-1744
Number of pages	5
Journal	CELL RESEARCH
Volume	21
Issue number	12
Early online date	22 Nov 2011
DOIs	https://doi.org/10.1038/cr.2011.186
Publication status	Published - Dec 2011

Keywords

Adenoviridae
Fibroblasts
Genetic Vectors
Hemoglobinopathies
Hemoglobins
Homologous Recombination
Humans
Induced Pluripotent Stem Cells
Mutation
Targeted Gene Repair

Access to Document

10.1038/cr.2011.186

Cite this

@article{018cc181675449688a97052830d82430,

title = "Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs",

keywords = "Adenoviridae, Fibroblasts, Genetic Vectors, Hemoglobinopathies, Hemoglobins, Homologous Recombination, Humans, Induced Pluripotent Stem Cells, Mutation, Targeted Gene Repair",

author = "Mo Li and Keiichiro Suzuki and Jing Qu and Preeti Saini and Ilir Dubova and Fei Yi and Jungmin Lee and Ignacio Sancho-Martinez and Guang-Hui Liu and {Izpisua Belmonte}, {Juan Carlos}",

year = "2011",

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doi = "10.1038/cr.2011.186",

language = "English",

volume = "21",

pages = "1740--1744",

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T1 - Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

AU - Li, Mo

AU - Suzuki, Keiichiro

AU - Qu, Jing

AU - Saini, Preeti

AU - Dubova, Ilir

AU - Yi, Fei

AU - Lee, Jungmin

AU - Sancho-Martinez, Ignacio

AU - Liu, Guang-Hui

AU - Izpisua Belmonte, Juan Carlos

PY - 2011/12

Y1 - 2011/12

KW - Adenoviridae

KW - Fibroblasts

KW - Genetic Vectors

KW - Hemoglobinopathies

KW - Hemoglobins

KW - Homologous Recombination

KW - Humans

KW - Induced Pluripotent Stem Cells

KW - Mutation

KW - Targeted Gene Repair

U2 - 10.1038/cr.2011.186

DO - 10.1038/cr.2011.186

M3 - Letter

C2 - 22105484

SN - 1001-0602

VL - 21

SP - 1740

EP - 1744

JO - CELL RESEARCH

JF - CELL RESEARCH

IS - 12

ER -