Environmental enrichment slows disease progression in R61/2 Huntington's disease mice

E Hockly; P M Cordery; B Woodman; A Mahal; A van Dellen; C Blakemore; C M Lewis; A J Hannan; G P Bates

doi:10.1002/ana.10094

Environmental enrichment slows disease progression in R61/2 Huntington's disease mice

E Hockly, P M Cordery, B Woodman, A Mahal, A van Dellen, C Blakemore, C M Lewis, A J Hannan, G P Bates

Medical & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

299 Citations (Scopus)

Abstract

Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease,progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the course of several neurological disorders. Environmentally enriched mice may actually mimic human disease more accurately. We found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal litter-mates, maximal enrichment was required to induce a marked improvement in behavioral tests. Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease.

Original language	English
Pages (from-to)	235 - 242
Number of pages	8
Journal	Annals of Neurology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/ana.10094
Publication status	Published - 2002

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title = "Environmental enrichment slows disease progression in R61/2 Huntington's disease mice",

abstract = "Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease,progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the course of several neurological disorders. Environmentally enriched mice may actually mimic human disease more accurately. We found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal litter-mates, maximal enrichment was required to induce a marked improvement in behavioral tests. Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease.",

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AU - Hockly, E

AU - Cordery, P M

AU - Woodman, B

AU - Mahal, A

AU - van Dellen, A

AU - Blakemore, C

AU - Lewis, C M

AU - Hannan, A J

AU - Bates, G P

PY - 2002

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AB - Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease,progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the course of several neurological disorders. Environmentally enriched mice may actually mimic human disease more accurately. We found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal litter-mates, maximal enrichment was required to induce a marked improvement in behavioral tests. Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease.

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Environmental enrichment slows disease progression in R61/2 Huntington's disease mice

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