Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin

X. Kodji; A.A. Aubdool; S.D. Brain

doi:10.1016/j.retram.2016.09.002

Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin

X. Kodji, A.A. Aubdool, S.D. Brain

Vascular Biology & Inflammation

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.

Original language	English
Journal	Current Research in Translational Medicine
Early online date	4 Nov 2016
DOIs	https://doi.org/10.1016/j.retram.2016.09.002
Publication status	E-pub ahead of print - 4 Nov 2016

Keywords

Sensory nerves
Transient receptor potential channels
Neuropeptides
Skin inflammation
Peripheral vasculature

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10.1016/j.retram.2016.09.002

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abstract = "This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.",

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KW - Sensory nerves

KW - Transient receptor potential channels

KW - Neuropeptides

KW - Skin inflammation

KW - Peripheral vasculature

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Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin

Abstract

Keywords

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