Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis

Muy-Teck Teh; Iain L Hutchison; Daniela Elena Costea; Evelyn Neppelberg; Per Gunnar Liavaag; Karin Purdie; Catherine Harwood; Hong Wan; Edward W Odell; Allan Hackshaw; Ahmad Waseem

doi:10.1002/ijc.27886

Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis

Muy-Teck Teh, Iain L Hutchison, Daniela Elena Costea, Evelyn Neppelberg, Per Gunnar Liavaag, Karin Purdie, Catherine Harwood, Hong Wan, Edward W Odell, Allan Hackshaw, Ahmad Waseem

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Histopathological discordance with molecular phenotype of many human cancers poses clinically challenging tasks for accurate cancer diagnosis which impacts on treatment strategy and patient outcome. Hence, an objective, accurate and quantitative method is needed. A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes. Their mRNA expression levels were translated via a prospectively designed algorithm, into a metric scoring system. Subjects from UK and Norway (n=299) provided 359 head and neck tissue specimens. Diagnostic test performance was assessed using detection rate (DR) and false-positive rate (FPR).The median qMIDS scores were 1.3, 2.9 and 6.7 in healthy tissue, dysplasia and head and neck squamous cell carcinomas (HNSCC), respectively (UK prospective dataset, p

Original language	English
Journal	International Journal of Cancer
DOIs	https://doi.org/10.1002/ijc.27886
Publication status	E-pub ahead of print - 2012

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title = "Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis",

abstract = "Histopathological discordance with molecular phenotype of many human cancers poses clinically challenging tasks for accurate cancer diagnosis which impacts on treatment strategy and patient outcome. Hence, an objective, accurate and quantitative method is needed. A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes. Their mRNA expression levels were translated via a prospectively designed algorithm, into a metric scoring system. Subjects from UK and Norway (n=299) provided 359 head and neck tissue specimens. Diagnostic test performance was assessed using detection rate (DR) and false-positive rate (FPR).The median qMIDS scores were 1.3, 2.9 and 6.7 in healthy tissue, dysplasia and head and neck squamous cell carcinomas (HNSCC), respectively (UK prospective dataset, p",

author = "Muy-Teck Teh and Hutchison, {Iain L} and Costea, {Daniela Elena} and Evelyn Neppelberg and Liavaag, {Per Gunnar} and Karin Purdie and Catherine Harwood and Hong Wan and Odell, {Edward W} and Allan Hackshaw and Ahmad Waseem",

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year = "2012",

doi = "10.1002/ijc.27886",

language = "English",

journal = "International Journal of Cancer",

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T1 - Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis

AU - Teh, Muy-Teck

AU - Hutchison, Iain L

AU - Costea, Daniela Elena

AU - Neppelberg, Evelyn

AU - Liavaag, Per Gunnar

AU - Purdie, Karin

AU - Harwood, Catherine

AU - Wan, Hong

AU - Odell, Edward W

AU - Hackshaw, Allan

AU - Waseem, Ahmad

PY - 2012

Y1 - 2012

N2 - Histopathological discordance with molecular phenotype of many human cancers poses clinically challenging tasks for accurate cancer diagnosis which impacts on treatment strategy and patient outcome. Hence, an objective, accurate and quantitative method is needed. A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes. Their mRNA expression levels were translated via a prospectively designed algorithm, into a metric scoring system. Subjects from UK and Norway (n=299) provided 359 head and neck tissue specimens. Diagnostic test performance was assessed using detection rate (DR) and false-positive rate (FPR).The median qMIDS scores were 1.3, 2.9 and 6.7 in healthy tissue, dysplasia and head and neck squamous cell carcinomas (HNSCC), respectively (UK prospective dataset, p

AB - Histopathological discordance with molecular phenotype of many human cancers poses clinically challenging tasks for accurate cancer diagnosis which impacts on treatment strategy and patient outcome. Hence, an objective, accurate and quantitative method is needed. A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes. Their mRNA expression levels were translated via a prospectively designed algorithm, into a metric scoring system. Subjects from UK and Norway (n=299) provided 359 head and neck tissue specimens. Diagnostic test performance was assessed using detection rate (DR) and false-positive rate (FPR).The median qMIDS scores were 1.3, 2.9 and 6.7 in healthy tissue, dysplasia and head and neck squamous cell carcinomas (HNSCC), respectively (UK prospective dataset, p

U2 - 10.1002/ijc.27886

DO - 10.1002/ijc.27886

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SN - 0020-7136

JO - International Journal of Cancer

JF - International Journal of Cancer

ER -

Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis

Abstract

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