TY - JOUR
T1 - Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression.
AU - Mitsiadis, T A
AU - Gayet, O
AU - Zhang, N
AU - Carroll, P
PY - 2001
Y1 - 2001
N2 - The Notch signalling pathway defines a phylogenetically conserved cell-cell communication process that enables cell-fate specification in multicellular organisms. Deltex is a component of the Notch signalling network that physically interacts with the ankyrin repeats of Notch. Here, we report on the expression pattern of the Deltex1 gene during mouse embryonic development and, furthermore, we compare its expression with that of the Notch1, 2 and 3 genes. Complementary and combinatorial expression patterns between Deltex1 and the three Notch genes were observed throughout embryogenesis since Deltex1 expression was related either to cytodifferentiation (i.e. neuronal tissues) or to cell proliferation events (i.e. eye, vascular structures, hematopoiesis).
AB - The Notch signalling pathway defines a phylogenetically conserved cell-cell communication process that enables cell-fate specification in multicellular organisms. Deltex is a component of the Notch signalling network that physically interacts with the ankyrin repeats of Notch. Here, we report on the expression pattern of the Deltex1 gene during mouse embryonic development and, furthermore, we compare its expression with that of the Notch1, 2 and 3 genes. Complementary and combinatorial expression patterns between Deltex1 and the three Notch genes were observed throughout embryogenesis since Deltex1 expression was related either to cytodifferentiation (i.e. neuronal tissues) or to cell proliferation events (i.e. eye, vascular structures, hematopoiesis).
U2 - 10.1016/S0925-4773(01)00534-2
DO - 10.1016/S0925-4773(01)00534-2
M3 - Article
VL - 109
SP - 399
EP - 403
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 2
ER -