TY - JOUR
T1 - Facile biosensors for rapid detection of COVID-19
AU - Xu, Lizhou
AU - Li, Danyang
AU - Ramadan, Sami
AU - Li, Yanbin
AU - Klein, Norbert
PY - 2020/12/15
Y1 - 2020/12/15
N2 - Currently the world is being challenged by a public health emergency caused by the coronavirus pandemic (COVID-19). Extensive efforts in testing for coronavirus infection, combined with isolating infected cases and quarantining those in contact, have proven successful in bringing the epidemic under control. Rapid and facile screening of this disease is in high demand. This review summarises recent advances in strategies reported by international researchers and engineers concerning how to tackle COVID-19 via rapid testing, mainly through nucleic acid- and antibody- testing. The roles of biosensors as powerful analytical tools are emphasized for the detection of viral RNAs, surface antigens, whole viral particles, antibodies and other potential biomarkers in human specimen. We critically review in depth newly developed biosensing methods especially for in-field and point-of-care detection of SARS-CoV-2. Additionally, this review describes possible future strategies for virus rapid detection. It helps researchers working on novel sensor technologies to tailor their technologies in a way to address the challenge for effective detection of COVID-19.
AB - Currently the world is being challenged by a public health emergency caused by the coronavirus pandemic (COVID-19). Extensive efforts in testing for coronavirus infection, combined with isolating infected cases and quarantining those in contact, have proven successful in bringing the epidemic under control. Rapid and facile screening of this disease is in high demand. This review summarises recent advances in strategies reported by international researchers and engineers concerning how to tackle COVID-19 via rapid testing, mainly through nucleic acid- and antibody- testing. The roles of biosensors as powerful analytical tools are emphasized for the detection of viral RNAs, surface antigens, whole viral particles, antibodies and other potential biomarkers in human specimen. We critically review in depth newly developed biosensing methods especially for in-field and point-of-care detection of SARS-CoV-2. Additionally, this review describes possible future strategies for virus rapid detection. It helps researchers working on novel sensor technologies to tailor their technologies in a way to address the challenge for effective detection of COVID-19.
KW - Biosensor
KW - Coronavirus
KW - COVID-19
KW - Point-of-care testing
KW - Rapid detection
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85092056343&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2020.112673
DO - 10.1016/j.bios.2020.112673
M3 - Article
AN - SCOPUS:85092056343
SN - 0956-5663
VL - 170
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 112673
ER -
