Familial liability to schizophrenia and premorbid adjustment

M Walshe; M Taylor; K Schulze; E Bramon; S Frangou; D Stahl; E Kravariti; E Daly; P Fearon; R M Murray; C McDonald

doi:10.1192/bjp.bp.106.033688

Familial liability to schizophrenia and premorbid adjustment

M Walshe, M Taylor, K Schulze, E Bramon, S Frangou, D Stahl, E Kravariti, E Daly, P Fearon, R M Murray, C McDonald

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Abstract

We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect

Original language	English
Pages (from-to)	260 - 261
Number of pages	2
Journal	British Journal of Psychiatry
Volume	191
Issue number	3
DOIs	https://doi.org/10.1192/bjp.bp.106.033688
Publication status	Published - Sept 2007

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10.1192/bjp.bp.106.033688

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AU - Walshe, M

AU - Taylor, M

AU - Schulze, K

AU - Bramon, E

AU - Frangou, S

AU - Stahl, D

AU - Kravariti, E

AU - Daly, E

AU - Fearon, P

AU - Murray, R M

AU - McDonald, C

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AB - We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect

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DO - 10.1192/bjp.bp.106.033688

M3 - Article

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JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

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Familial liability to schizophrenia and premorbid adjustment

Abstract

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