TY - JOUR
T1 - Frailty modifications and prognostic impact in older patients admitted in acute care
AU - Basile, Giorgio
AU - Catalano, Antonino
AU - Mandraffino, Giuseppe
AU - Maltese, Giuseppe
AU - Alibrandi, Angela
AU - Ciancio, Giuliana
AU - Brischetto, Daniela
AU - Morabito, Nunziata
AU - Lasco, Antonino
AU - Cesari, Matteo
PY - 2019/1/25
Y1 - 2019/1/25
N2 - Background
Frailty is a predictor of adverse outcomes in older subjects.
Aims
The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes.
Methods
Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge.
Results
A statistically significant difference was reported between the aFI (0.31, IQR 0.19–0.44) and the dFI (0.29, IQR 0.19–0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0–17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4–12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2–17.9, p = 0.03).
Conclusion
Frailty is a strong predictor of negative endpoints in hospitalized older persons.
Discussion
Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
AB - Background
Frailty is a predictor of adverse outcomes in older subjects.
Aims
The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes.
Methods
Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge.
Results
A statistically significant difference was reported between the aFI (0.31, IQR 0.19–0.44) and the dFI (0.29, IQR 0.19–0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0–17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4–12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2–17.9, p = 0.03).
Conclusion
Frailty is a strong predictor of negative endpoints in hospitalized older persons.
Discussion
Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
U2 - 10.1007/s40520-018-0989-7
DO - 10.1007/s40520-018-0989-7
M3 - Article
SN - 1720-8319
VL - 31
SP - 151
EP - 155
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 1
ER -