Frequency and pressure dependent attenuation and scattering by microbubbles

Meng-Xing Tang; Robert J. Eckersley

doi:10.1016/j.ultrasmedbio.2006.07.031

Frequency and pressure dependent attenuation and scattering by microbubbles

Meng-Xing Tang^*, Robert J. Eckersley

^*Corresponding author for this work

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

The aim of this study was to evaluate experimentally the degree of pressure dependence of attenuation and scattering by microbubbles at low acoustic pressures with an empirical nonlinear model. In addition, the pressure dependency over a range of frequencies (1 to 5 MHz) has been studied. A series of transmission and scattering measurements were made with the microbubble SonoVue (TM), using an automated system. Results show that, within the pressure range studied, attenuation as a result of the microbubble is pressure-dependent, whereas no such dependence of scattering was detectable. The pressure dependence of attenuation for SonoVue (TM) was found to be most significant at 1.5 MHz. The scattering is shown to be the highest at the lowest insonation frequency, around 1 similar to 1.25 MHz, and then decreases with frequency. (E-mail: [email protected]) (c) 2006 World Federation for Ultrasound in Medicine & Biology.

Original language	English
Pages (from-to)	164-168
Number of pages	5
Journal	Ultrasound in Medicine and Biology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2006.07.031
Publication status	Published - Jan 2007

Keywords

ultrasound contrast agent
attenuation
scattering
pressure dependency
microbubbles
multifrequency
ULTRASOUND CONTRAST AGENTS
BACKSCATTER

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10.1016/j.ultrasmedbio.2006.07.031

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title = "Frequency and pressure dependent attenuation and scattering by microbubbles",

abstract = "The aim of this study was to evaluate experimentally the degree of pressure dependence of attenuation and scattering by microbubbles at low acoustic pressures with an empirical nonlinear model. In addition, the pressure dependency over a range of frequencies (1 to 5 MHz) has been studied. A series of transmission and scattering measurements were made with the microbubble SonoVue (TM), using an automated system. Results show that, within the pressure range studied, attenuation as a result of the microbubble is pressure-dependent, whereas no such dependence of scattering was detectable. The pressure dependence of attenuation for SonoVue (TM) was found to be most significant at 1.5 MHz. The scattering is shown to be the highest at the lowest insonation frequency, around 1 similar to 1.25 MHz, and then decreases with frequency. (E-mail: [email protected]) (c) 2006 World Federation for Ultrasound in Medicine & Biology.",

keywords = "ultrasound contrast agent, attenuation, scattering, pressure dependency, microbubbles, multifrequency, ULTRASOUND CONTRAST AGENTS, BACKSCATTER",

author = "Meng-Xing Tang and Eckersley, {Robert J.}",

year = "2007",

month = jan,

doi = "10.1016/j.ultrasmedbio.2006.07.031",

language = "English",

volume = "33",

pages = "164--168",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

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TY - JOUR

T1 - Frequency and pressure dependent attenuation and scattering by microbubbles

AU - Tang, Meng-Xing

AU - Eckersley, Robert J.

PY - 2007/1

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N2 - The aim of this study was to evaluate experimentally the degree of pressure dependence of attenuation and scattering by microbubbles at low acoustic pressures with an empirical nonlinear model. In addition, the pressure dependency over a range of frequencies (1 to 5 MHz) has been studied. A series of transmission and scattering measurements were made with the microbubble SonoVue (TM), using an automated system. Results show that, within the pressure range studied, attenuation as a result of the microbubble is pressure-dependent, whereas no such dependence of scattering was detectable. The pressure dependence of attenuation for SonoVue (TM) was found to be most significant at 1.5 MHz. The scattering is shown to be the highest at the lowest insonation frequency, around 1 similar to 1.25 MHz, and then decreases with frequency. (E-mail: [email protected]) (c) 2006 World Federation for Ultrasound in Medicine & Biology.

AB - The aim of this study was to evaluate experimentally the degree of pressure dependence of attenuation and scattering by microbubbles at low acoustic pressures with an empirical nonlinear model. In addition, the pressure dependency over a range of frequencies (1 to 5 MHz) has been studied. A series of transmission and scattering measurements were made with the microbubble SonoVue (TM), using an automated system. Results show that, within the pressure range studied, attenuation as a result of the microbubble is pressure-dependent, whereas no such dependence of scattering was detectable. The pressure dependence of attenuation for SonoVue (TM) was found to be most significant at 1.5 MHz. The scattering is shown to be the highest at the lowest insonation frequency, around 1 similar to 1.25 MHz, and then decreases with frequency. (E-mail: [email protected]) (c) 2006 World Federation for Ultrasound in Medicine & Biology.

KW - ultrasound contrast agent

KW - attenuation

KW - scattering

KW - pressure dependency

KW - microbubbles

KW - multifrequency

KW - ULTRASOUND CONTRAST AGENTS

KW - BACKSCATTER

U2 - 10.1016/j.ultrasmedbio.2006.07.031

DO - 10.1016/j.ultrasmedbio.2006.07.031

M3 - Article

SN - 0301-5629

VL - 33

SP - 164

EP - 168

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 1

ER -

Frequency and pressure dependent attenuation and scattering by microbubbles

Abstract

Keywords

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