Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

G. B. Rogers; J. Kozlowska; J. Keeble; K. Metcalfe; M. Fao; S. E. Dowd; A. J. Mason; M. A. McGuckin; K. D. Bruce

doi:10.1038/srep05437

Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

G. B. Rogers^*, J. Kozlowska, J. Keeble, K. Metcalfe, M. Fao, S. E. Dowd, A. J. Mason, M. A. McGuckin, K. D. Bruce

^*Corresponding author for this work

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

113 Downloads (Pure)

Abstract

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

Original language	English
Article number	5437
Number of pages	5
Journal	Scientific Reports
Volume	4
Early online date	25 Jun 2014
DOIs	https://doi.org/10.1038/srep05437
Publication status	Published - 2015

Keywords

AMPLICON PYROSEQUENCING BTEFAP
GUT MICROBIOTA
BACTERIAL DIVERSITY
COLONIC MICROBIOTA
OBESITY
METABOLOMICS
BEHAVIOR
HEALTH
CANCER
DIET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/srep05437Licence: CC BY-NC-ND

Functional divergence in gastrointestinal_ROGERS_Accepted5June2014_GOLD VoRFinal published version, 1.13 MBLicence: CC BY-NC-ND

Cite this

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title = "Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice",

abstract = "Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.",

keywords = "AMPLICON PYROSEQUENCING BTEFAP, GUT MICROBIOTA, BACTERIAL DIVERSITY, COLONIC MICROBIOTA, OBESITY, METABOLOMICS, BEHAVIOR, HEALTH, CANCER, DIET",

author = "Rogers, {G. B.} and J. Kozlowska and J. Keeble and K. Metcalfe and M. Fao and Dowd, {S. E.} and Mason, {A. J.} and McGuckin, {M. A.} and Bruce, {K. D.}",

year = "2015",

doi = "10.1038/srep05437",

language = "English",

volume = "4",

journal = "Scientific Reports",

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T1 - Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

AU - Rogers, G. B.

AU - Kozlowska, J.

AU - Keeble, J.

AU - Metcalfe, K.

AU - Fao, M.

AU - Dowd, S. E.

AU - Mason, A. J.

AU - McGuckin, M. A.

AU - Bruce, K. D.

PY - 2015

Y1 - 2015

N2 - Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

AB - Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

KW - AMPLICON PYROSEQUENCING BTEFAP

KW - GUT MICROBIOTA

KW - BACTERIAL DIVERSITY

KW - COLONIC MICROBIOTA

KW - OBESITY

KW - METABOLOMICS

KW - BEHAVIOR

KW - HEALTH

KW - CANCER

KW - DIET

U2 - 10.1038/srep05437

DO - 10.1038/srep05437

M3 - Article

SN - 2045-2322

VL - 4

JO - Scientific Reports

JF - Scientific Reports

M1 - 5437

ER -

Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Abstract

Keywords

UN SDGs

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