Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts

B L Browning; V Annese; M L Barclay; S A Bingham; S Brand; C Buning; M Castro; S Cucchiara; B Dallapiccola; H Drummond; L R Ferguson; A Ferraris; S A Fisher; R B Gearry; J Glas; L Henckaerts; C Huebner; D Knafelz; L Lakatos; P L Lakatos; A Latiano; X Liu; C Mathew; B Muller-Myhsok; W G Newman; E R Nimmo; C L Noble; O Palmieri; M Parkes; I Petermann; P Rutgeerts; J Satsangi; A N Shelling; K A Siminovitch; H P Torok; M Tremelling; S Vermeire; M R Valvano; H Witt

doi:10.1136/jmg.2007.050773

Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts

B L Browning, V Annese, M L Barclay, S A Bingham, S Brand, C Buning, M Castro, S Cucchiara, B Dallapiccola, H Drummond, L R Ferguson, A Ferraris, S A Fisher, R B Gearry, J Glas, L Henckaerts, C Huebner, D Knafelz, L Lakatos, P L LakatosA Latiano, X Liu, C Mathew, B Muller-Myhsok, W G Newman, E R Nimmo, C L Noble, O Palmieri, M Parkes, I Petermann, P Rutgeerts, J Satsangi, A N Shelling, K A Siminovitch, H P Torok, M Tremelling, S Vermeire, M R Valvano, H Witt

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Background: DLG5 p. R30Q has been reported to be associated with Crohn disease ( CD), but this association has not been replicated in most studies. A recent analysis of gender-stratified data from two case-control studies and two population cohorts found an association of DLG5 30Q with increased risk of CD in men but not in women and found differences between 30Q population frequencies for males and females. Male-female differences in population allele frequencies and male-specific risk could explain the difficulty in replicating the association with CD. Methods: DLG5 R30Q genotype data were collected for patients with CD and controls from 11 studies that did not include gender-stratified allele counts in their published reports and tested for male-female frequency differences in controls and for case-control frequency differences in men and in women. Results: The data showed no male-female allele frequency differences in controls. An exact conditional test gave marginal evidence that 30Q is associated with decreased risk of CD in women (p= 0.049, OR= 0.87, 95% CI 0.77 to 1.00). There was also a trend towards reduced 30Q frequencies in male patients with CD compared with male controls, but this was not significant at the 0.05 level (p = 0.058, OR= 0.87, 95% CI 0.74 to 1.01). When data from this study were combined with previously published, gender-stratified data, the 30Q allele was found to be associated with decreased risk of CD in women (p= 0.010, OR= 0.86, 95% CI 0.76 to 0.97), but not in men. Conclusion: DLG5 30Q is associated with a small reduction in risk of CD in women

Original language	English
Pages (from-to)	36 - 42
Number of pages	7
Journal	Journal of Medical Genetics
Volume	45
Issue number	1
DOIs	https://doi.org/10.1136/jmg.2007.050773
Publication status	Published - Jan 2008

Access to Document

10.1136/jmg.2007.050773

Cite this

Browning, B. L., Annese, V., Barclay, M. L., Bingham, S. A., Brand, S., Buning, C., Castro, M., Cucchiara, S., Dallapiccola, B., Drummond, H., Ferguson, L. R., Ferraris, A., Fisher, S. A., Gearry, R. B., Glas, J., Henckaerts, L., Huebner, C., Knafelz, D., Lakatos, L., ... Witt, H. (2008). Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. Journal of Medical Genetics, 45(1), 36 - 42. https://doi.org/10.1136/jmg.2007.050773

@article{7923f53225974c4a91c47dee154c5625,

title = "Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts",

abstract = "Background: DLG5 p. R30Q has been reported to be associated with Crohn disease ( CD), but this association has not been replicated in most studies. A recent analysis of gender-stratified data from two case-control studies and two population cohorts found an association of DLG5 30Q with increased risk of CD in men but not in women and found differences between 30Q population frequencies for males and females. Male-female differences in population allele frequencies and male-specific risk could explain the difficulty in replicating the association with CD. Methods: DLG5 R30Q genotype data were collected for patients with CD and controls from 11 studies that did not include gender-stratified allele counts in their published reports and tested for male-female frequency differences in controls and for case-control frequency differences in men and in women. Results: The data showed no male-female allele frequency differences in controls. An exact conditional test gave marginal evidence that 30Q is associated with decreased risk of CD in women (p= 0.049, OR= 0.87, 95% CI 0.77 to 1.00). There was also a trend towards reduced 30Q frequencies in male patients with CD compared with male controls, but this was not significant at the 0.05 level (p = 0.058, OR= 0.87, 95% CI 0.74 to 1.01). When data from this study were combined with previously published, gender-stratified data, the 30Q allele was found to be associated with decreased risk of CD in women (p= 0.010, OR= 0.86, 95% CI 0.76 to 0.97), but not in men. Conclusion: DLG5 30Q is associated with a small reduction in risk of CD in women",

author = "Browning, {B L} and V Annese and Barclay, {M L} and Bingham, {S A} and S Brand and C Buning and M Castro and S Cucchiara and B Dallapiccola and H Drummond and Ferguson, {L R} and A Ferraris and Fisher, {S A} and Gearry, {R B} and J Glas and L Henckaerts and C Huebner and D Knafelz and L Lakatos and Lakatos, {P L} and A Latiano and X Liu and C Mathew and B Muller-Myhsok and Newman, {W G} and Nimmo, {E R} and Noble, {C L} and O Palmieri and M Parkes and I Petermann and P Rutgeerts and J Satsangi and Shelling, {A N} and Siminovitch, {K A} and Torok, {H P} and M Tremelling and S Vermeire and Valvano, {M R} and H Witt",

year = "2008",

month = jan,

doi = "10.1136/jmg.2007.050773",

language = "English",

volume = "45",

pages = "36 -- 42",

journal = "Journal of Medical Genetics",

issn = "1468-6244",

publisher = "B M J PUBLISHING GROUP",

number = "1",

}

Browning, BL, Annese, V, Barclay, ML, Bingham, SA, Brand, S, Buning, C, Castro, M, Cucchiara, S, Dallapiccola, B, Drummond, H, Ferguson, LR, Ferraris, A, Fisher, SA, Gearry, RB, Glas, J, Henckaerts, L, Huebner, C, Knafelz, D, Lakatos, L, Lakatos, PL, Latiano, A, Liu, X, Mathew, C, Muller-Myhsok, B, Newman, WG, Nimmo, ER, Noble, CL, Palmieri, O, Parkes, M, Petermann, I, Rutgeerts, P, Satsangi, J, Shelling, AN, Siminovitch, KA, Torok, HP, Tremelling, M, Vermeire, S, Valvano, MR & Witt, H 2008, 'Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts', Journal of Medical Genetics, vol. 45, no. 1, pp. 36 - 42. https://doi.org/10.1136/jmg.2007.050773

TY - JOUR

T1 - Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts

AU - Browning, B L

AU - Annese, V

AU - Barclay, M L

AU - Bingham, S A

AU - Brand, S

AU - Buning, C

AU - Castro, M

AU - Cucchiara, S

AU - Dallapiccola, B

AU - Drummond, H

AU - Ferguson, L R

AU - Ferraris, A

AU - Fisher, S A

AU - Gearry, R B

AU - Glas, J

AU - Henckaerts, L

AU - Huebner, C

AU - Knafelz, D

AU - Lakatos, L

AU - Lakatos, P L

AU - Latiano, A

AU - Liu, X

AU - Mathew, C

AU - Muller-Myhsok, B

AU - Newman, W G

AU - Nimmo, E R

AU - Noble, C L

AU - Palmieri, O

AU - Parkes, M

AU - Petermann, I

AU - Rutgeerts, P

AU - Satsangi, J

AU - Shelling, A N

AU - Siminovitch, K A

AU - Torok, H P

AU - Tremelling, M

AU - Vermeire, S

AU - Valvano, M R

AU - Witt, H

PY - 2008/1

Y1 - 2008/1

N2 - Background: DLG5 p. R30Q has been reported to be associated with Crohn disease ( CD), but this association has not been replicated in most studies. A recent analysis of gender-stratified data from two case-control studies and two population cohorts found an association of DLG5 30Q with increased risk of CD in men but not in women and found differences between 30Q population frequencies for males and females. Male-female differences in population allele frequencies and male-specific risk could explain the difficulty in replicating the association with CD. Methods: DLG5 R30Q genotype data were collected for patients with CD and controls from 11 studies that did not include gender-stratified allele counts in their published reports and tested for male-female frequency differences in controls and for case-control frequency differences in men and in women. Results: The data showed no male-female allele frequency differences in controls. An exact conditional test gave marginal evidence that 30Q is associated with decreased risk of CD in women (p= 0.049, OR= 0.87, 95% CI 0.77 to 1.00). There was also a trend towards reduced 30Q frequencies in male patients with CD compared with male controls, but this was not significant at the 0.05 level (p = 0.058, OR= 0.87, 95% CI 0.74 to 1.01). When data from this study were combined with previously published, gender-stratified data, the 30Q allele was found to be associated with decreased risk of CD in women (p= 0.010, OR= 0.86, 95% CI 0.76 to 0.97), but not in men. Conclusion: DLG5 30Q is associated with a small reduction in risk of CD in women

AB - Background: DLG5 p. R30Q has been reported to be associated with Crohn disease ( CD), but this association has not been replicated in most studies. A recent analysis of gender-stratified data from two case-control studies and two population cohorts found an association of DLG5 30Q with increased risk of CD in men but not in women and found differences between 30Q population frequencies for males and females. Male-female differences in population allele frequencies and male-specific risk could explain the difficulty in replicating the association with CD. Methods: DLG5 R30Q genotype data were collected for patients with CD and controls from 11 studies that did not include gender-stratified allele counts in their published reports and tested for male-female frequency differences in controls and for case-control frequency differences in men and in women. Results: The data showed no male-female allele frequency differences in controls. An exact conditional test gave marginal evidence that 30Q is associated with decreased risk of CD in women (p= 0.049, OR= 0.87, 95% CI 0.77 to 1.00). There was also a trend towards reduced 30Q frequencies in male patients with CD compared with male controls, but this was not significant at the 0.05 level (p = 0.058, OR= 0.87, 95% CI 0.74 to 1.01). When data from this study were combined with previously published, gender-stratified data, the 30Q allele was found to be associated with decreased risk of CD in women (p= 0.010, OR= 0.86, 95% CI 0.76 to 0.97), but not in men. Conclusion: DLG5 30Q is associated with a small reduction in risk of CD in women

U2 - 10.1136/jmg.2007.050773

DO - 10.1136/jmg.2007.050773

M3 - Article

SN - 1468-6244

VL - 45

SP - 36

EP - 42

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 1

ER -

Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts

Abstract

Access to Document

Fingerprint

Cite this