Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma

Charlotte Elizabeth Graham; Agnieszka Jozwik; Ruby Quartey-Papafio; Nikolaos Ioannou; Ana M. Metelo; Carlo Scala; Glenda Dickson; Orla Stewart; Maria Almena-Carrasco; Elisa Peranzoni; Alan G. Ramsay; Piers E.M. Patten; Thomas Pertel; Farzin Farzaneh; Sandra Dupouy; Andrea Pepper; Reuben Benjamin

doi:10.1038/s41375-021-01324-z

Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma

Charlotte Elizabeth Graham^*, Agnieszka Jozwik, Ruby Quartey-Papafio, Nikolaos Ioannou, Ana M. Metelo, Carlo Scala, Glenda Dickson, Orla Stewart, Maria Almena-Carrasco, Elisa Peranzoni, Alan G. Ramsay, Piers E.M. Patten, Thomas Pertel, Farzin Farzaneh, Sandra Dupouy, Andrea Pepper, Reuben Benjamin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Original language	English
Pages (from-to)	3581-3584
Number of pages	4
Journal	Leukemia
Volume	35
Issue number	12
Early online date	18 Jun 2021
DOIs	https://doi.org/10.1038/s41375-021-01324-z
Publication status	Published - Dec 2021

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10.1038/s41375-021-01324-z

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Graham, C. E., Jozwik, A., Quartey-Papafio, R., Ioannou, N., Metelo, A. M., Scala, C., Dickson, G., Stewart, O., Almena-Carrasco, M., Peranzoni, E., Ramsay, A. G., Patten, P. E. M., Pertel, T., Farzaneh, F., Dupouy, S., Pepper, A., & Benjamin, R. (2021). Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma. Leukemia, 35(12), 3581-3584. https://doi.org/10.1038/s41375-021-01324-z

@article{ec9bfc4b3c7f4ad0bae12e8aa73c1b46,

title = "Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma",

author = "Graham, {Charlotte Elizabeth} and Agnieszka Jozwik and Ruby Quartey-Papafio and Nikolaos Ioannou and Metelo, {Ana M.} and Carlo Scala and Glenda Dickson and Orla Stewart and Maria Almena-Carrasco and Elisa Peranzoni and Ramsay, {Alan G.} and Patten, {Piers E.M.} and Thomas Pertel and Farzin Farzaneh and Sandra Dupouy and Andrea Pepper and Reuben Benjamin",

note = "Funding Information: This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and King{\textquoteright}s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Research funding was provided by Servier. Allogeneic CAR T-cell products targeting CD19 gene-edited by TALEN{\textregistered} are exclusively licensed to Servier from Cellectis and use Cellectis{\textquoteright} technologies. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = dec,

doi = "10.1038/s41375-021-01324-z",

language = "English",

volume = "35",

pages = "3581--3584",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature [academic journals on nature.com]",

number = "12",

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Graham, CE, Jozwik, A, Quartey-Papafio, R , Ioannou, N, Metelo, AM, Scala, C, Dickson, G, Stewart, O, Almena-Carrasco, M, Peranzoni, E, Ramsay, AG , Patten, PEM, Pertel, T, Farzaneh, F, Dupouy, S, Pepper, A & Benjamin, R 2021, 'Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma', Leukemia, vol. 35, no. 12, pp. 3581-3584. https://doi.org/10.1038/s41375-021-01324-z

Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma. / Graham, Charlotte Elizabeth; Jozwik, Agnieszka; Quartey-Papafio, Ruby et al.
In: Leukemia, Vol. 35, No. 12, 12.2021, p. 3581-3584.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma

AU - Graham, Charlotte Elizabeth

AU - Jozwik, Agnieszka

AU - Quartey-Papafio, Ruby

AU - Ioannou, Nikolaos

AU - Metelo, Ana M.

AU - Scala, Carlo

AU - Dickson, Glenda

AU - Stewart, Orla

AU - Almena-Carrasco, Maria

AU - Peranzoni, Elisa

AU - Ramsay, Alan G.

AU - Patten, Piers E.M.

AU - Pertel, Thomas

AU - Farzaneh, Farzin

AU - Dupouy, Sandra

AU - Pepper, Andrea

AU - Benjamin, Reuben

N1 - Funding Information: This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Research funding was provided by Servier. Allogeneic CAR T-cell products targeting CD19 gene-edited by TALEN® are exclusively licensed to Servier from Cellectis and use Cellectis’ technologies. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12

Y1 - 2021/12

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U2 - 10.1038/s41375-021-01324-z

DO - 10.1038/s41375-021-01324-z

M3 - Article

AN - SCOPUS:85108236469

SN - 0887-6924

VL - 35

SP - 3581

EP - 3584

JO - Leukemia

JF - Leukemia

IS - 12

ER -

Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma

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