Abstract
Empirical studies suggest that psychiatric disorders result from a complex interplay between genetic and environmental factors. Most evidence for such gene-environment interaction (GxE) is based on single candidate gene studies conducted from a Diathesis-Stress perspective. Recognizing the short-comings of candidate gene studies, GxE research has begun to focus on genome-wide and polygenic approaches as well as drawing on different theoretical concepts underlying GxE, such as Differential Susceptibility. After reviewing evidence from candidate GxE studies and presenting alternative theoretical frameworks underpinning GxE research, more recent approaches and findings from whole genome approaches are presented. Finally, we suggest how future GxE studies may unpick the complex interplay between genes and environments in psychiatric disorders.
Original language | English |
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Pages (from-to) | 133-143 |
Number of pages | 11 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 77 |
DOIs | |
Publication status | Published - May 2018 |
Keywords
- Antisocial Personality Disorder/genetics
- Attention Deficit Disorder with Hyperactivity/genetics
- Catechol O-Methyltransferase/genetics
- Depression/genetics
- Environment
- Gene-Environment Interaction
- Genetic Predisposition to Disease/genetics
- Humans
- Mental Disorders/genetics
- Monoamine Oxidase/genetics
- Receptors, Dopamine D4/genetics
- Schizophrenia/genetics
- Serotonin Plasma Membrane Transport Proteins/genetics
- Stress, Psychological/genetics