Genetics of Psoriasis

Satveer K Mahil; Francesca Capon; Jonathan N Barker

doi:10.1016/j.det.2014.09.001

Genetics of Psoriasis

Satveer K Mahil, Francesca Capon, Jonathan N Barker

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Psoriasis is a common and debilitating immune-mediated skin disease with a complex genetic basis. Genetic studies have provided critical insights into the pathogenesis of disease. This article focuses on the results of genetic association studies, which provide evidence that psoriasis susceptibility genes are involved in innate and adaptive immunity and skin barrier functions. The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Dermatologic clinics
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.det.2014.09.001
Publication status	Published - Jan 2015

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10.1016/j.det.2014.09.001

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title = "Genetics of Psoriasis",

abstract = "Psoriasis is a common and debilitating immune-mediated skin disease with a complex genetic basis. Genetic studies have provided critical insights into the pathogenesis of disease. This article focuses on the results of genetic association studies, which provide evidence that psoriasis susceptibility genes are involved in innate and adaptive immunity and skin barrier functions. The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted.",

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AB - Psoriasis is a common and debilitating immune-mediated skin disease with a complex genetic basis. Genetic studies have provided critical insights into the pathogenesis of disease. This article focuses on the results of genetic association studies, which provide evidence that psoriasis susceptibility genes are involved in innate and adaptive immunity and skin barrier functions. The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted.

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JO - Dermatologic clinics

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Genetics of Psoriasis

Abstract

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