Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

Rita Guerreiro; Valentina Escott-Price; Lee Darwent; Laura Parkkinen; Olaf Ansorge; Dena G. Hernandez; Michael A. Nalls; Lorraine Clark; Lawrence Honig; Karen Marder; Wiesje van der Flier; Henne Holstege; Eva Louwersheimer; Afina Lemstra; Philip Scheltens; Ekaterina Rogaeva; Peter St George-Hyslop; Elisabet Londos; Henrik Zetterberg; Sara Ortega-Cubero; Pau Pastor; Tanis J. Ferman; Neill R. Graff-Radford; Owen A. Ross; Imelda Barber; Anne Braae; Kristelle Brown; Kevin Morgan; Walter Maetzler; Daniela Berg; Claire Troakes; Safa Al-Sarraj; Tammaryn Lashley; Yaroslau Compta; Tamas Revesz; Andrew Lees; Nigel J. Cairns; Glenda M. Halliday; David Mann; Stuart Pickering-Brown; John Powell; Katie Lunnon; Michelle K. Lupton; Dennis Dickson; John Hardy; Andrew Singleton; Jose Bras

doi:10.1016/j.neurobiolaging.2015.10.028

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

Rita Guerreiro, Valentina Escott-Price, Lee Darwent, Laura Parkkinen, Olaf Ansorge, Dena G. Hernandez, Michael A. Nalls, Lorraine Clark, Lawrence Honig, Karen Marder, Wiesje van der Flier, Henne Holstege, Eva Louwersheimer, Afina Lemstra, Philip Scheltens, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Sara Ortega-CuberoPau Pastor, Tanis J. Ferman, Neill R. Graff-Radford, Owen A. Ross, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Walter Maetzler, Daniela Berg, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Yaroslau Compta, Tamas Revesz, Andrew Lees, Nigel J. Cairns, Glenda M. Halliday, David Mann, Stuart Pickering-Brown, John Powell, Katie Lunnon, Michelle K. Lupton, Dennis Dickson, John Hardy, Andrew Singleton, Jose Bras

Basic and Clinical Neuroscience

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69 Citations (Scopus)

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Abstract

The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

Original language	English
Pages (from-to)	214.e7–214.e10
Journal	Neurobiology of Aging
Volume	38
Early online date	2 Nov 2015
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.10.028
Publication status	Published - 1 Feb 2016

Keywords

Alzheimer's disease
Dementia with Lewy bodies
Genetic correlation
Parkinson's disease

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Genome-wide analysis_GUERREIRO_Firstonline2November2015_GOLD VoR (CC-BY)Final published version, 241 KBLicence: CC BY

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Guerreiro, R., Escott-Price, V., Darwent, L., Parkkinen, L., Ansorge, O., Hernandez, D. G., Nalls, M. A., Clark, L., Honig, L., Marder, K., van der Flier, W., Holstege, H., Louwersheimer, E., Lemstra, A., Scheltens, P., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H., ... Bras, J. (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging, 38, 214.e7–214.e10. https://doi.org/10.1016/j.neurobiolaging.2015.10.028

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title = "Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases",

abstract = "The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. ",

keywords = "Alzheimer's disease, Dementia with Lewy bodies, Genetic correlation, Parkinson's disease",

author = "Rita Guerreiro and Valentina Escott-Price and Lee Darwent and Laura Parkkinen and Olaf Ansorge and Hernandez, {Dena G.} and Nalls, {Michael A.} and Lorraine Clark and Lawrence Honig and Karen Marder and {van der Flier}, Wiesje and Henne Holstege and Eva Louwersheimer and Afina Lemstra and Philip Scheltens and Ekaterina Rogaeva and {St George-Hyslop}, Peter and Elisabet Londos and Henrik Zetterberg and Sara Ortega-Cubero and Pau Pastor and Ferman, {Tanis J.} and Graff-Radford, {Neill R.} and Ross, {Owen A.} and Imelda Barber and Anne Braae and Kristelle Brown and Kevin Morgan and Walter Maetzler and Daniela Berg and Claire Troakes and Safa Al-Sarraj and Tammaryn Lashley and Yaroslau Compta and Tamas Revesz and Andrew Lees and Cairns, {Nigel J.} and Halliday, {Glenda M.} and David Mann and Stuart Pickering-Brown and John Powell and Katie Lunnon and Lupton, {Michelle K.} and Dennis Dickson and John Hardy and Andrew Singleton and Jose Bras",

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Guerreiro, R, Escott-Price, V, Darwent, L, Parkkinen, L, Ansorge, O, Hernandez, DG, Nalls, MA, Clark, L, Honig, L, Marder, K, van der Flier, W, Holstege, H, Louwersheimer, E, Lemstra, A, Scheltens, P, Rogaeva, E, St George-Hyslop, P, Londos, E, Zetterberg, H, Ortega-Cubero, S, Pastor, P, Ferman, TJ, Graff-Radford, NR, Ross, OA, Barber, I, Braae, A, Brown, K, Morgan, K, Maetzler, W, Berg, D, Troakes, C , Al-Sarraj, S, Lashley, T, Compta, Y, Revesz, T, Lees, A, Cairns, NJ, Halliday, GM, Mann, D, Pickering-Brown, S, Powell, J, Lunnon, K, Lupton, MK, Dickson, D, Hardy, J, Singleton, A & Bras, J 2016, 'Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases', Neurobiology of Aging, vol. 38, pp. 214.e7–214.e10. https://doi.org/10.1016/j.neurobiolaging.2015.10.028

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AU - Guerreiro, Rita

AU - Escott-Price, Valentina

AU - Darwent, Lee

AU - Parkkinen, Laura

AU - Ansorge, Olaf

AU - Hernandez, Dena G.

AU - Nalls, Michael A.

AU - Clark, Lorraine

AU - Honig, Lawrence

AU - Marder, Karen

AU - van der Flier, Wiesje

AU - Holstege, Henne

AU - Louwersheimer, Eva

AU - Lemstra, Afina

AU - Scheltens, Philip

AU - Rogaeva, Ekaterina

AU - St George-Hyslop, Peter

AU - Londos, Elisabet

AU - Zetterberg, Henrik

AU - Ortega-Cubero, Sara

AU - Pastor, Pau

AU - Ferman, Tanis J.

AU - Graff-Radford, Neill R.

AU - Ross, Owen A.

AU - Barber, Imelda

AU - Braae, Anne

AU - Brown, Kristelle

AU - Morgan, Kevin

AU - Maetzler, Walter

AU - Berg, Daniela

AU - Troakes, Claire

AU - Al-Sarraj, Safa

AU - Lashley, Tammaryn

AU - Compta, Yaroslau

AU - Revesz, Tamas

AU - Lees, Andrew

AU - Cairns, Nigel J.

AU - Halliday, Glenda M.

AU - Mann, David

AU - Pickering-Brown, Stuart

AU - Powell, John

AU - Lunnon, Katie

AU - Lupton, Michelle K.

AU - Dickson, Dennis

AU - Hardy, John

AU - Singleton, Andrew

AU - Bras, Jose

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N2 - The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

AB - The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

KW - Alzheimer's disease

KW - Dementia with Lewy bodies

KW - Genetic correlation

KW - Parkinson's disease

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U2 - 10.1016/j.neurobiolaging.2015.10.028

DO - 10.1016/j.neurobiolaging.2015.10.028

M3 - Article

C2 - 26643944

AN - SCOPUS:84948808791

SN - 0197-4580

VL - 38

SP - 214.e7–214.e10

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

Abstract

Keywords

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