Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

J C Barrett; S Hansoul; D L Nicolae; J H Cho; R H Duerr; J D Rioux; S R Brant; M S Silverberg; K D Taylor; M M Barmada; A Bitton; T Dassopoulos; L W Datta; T Green; A M Griffiths; E O Kistner; M T Murtha; M D Regueiro; J I Rotter; L P Schumm; A H Steinhart; S R Targan; R J Xavier; C Libioulle; C Sandor; M Lathrop; J Belaiche; O Dewit; I Gut; S Heath; D Laukens; M Mni; P Rutgeerts; A Van Gossum; D Zelenika; D Franchimont; J P Hugot; M de Vos; S Vermeire; E Louis; L R Cardon; C A Anderson; H Drummond; E Nimmo; T Ahmad; N J Prescott; C M Onnie; S A Fisher; J Marchini; J Ghori; S Bumpstead; R Gwilliam; M Tremelling; P Deloukas; J Mansfield; D Jewell; J Satsangi; C G Mathew; M Parkes; M Georges; M J Daly

doi:10.1038/ng.175

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

J C Barrett, S Hansoul, D L Nicolae, J H Cho, R H Duerr, J D Rioux, S R Brant, M S Silverberg, K D Taylor, M M Barmada, A Bitton, T Dassopoulos, L W Datta, T Green, A M Griffiths, E O Kistner, M T Murtha, M D Regueiro, J I Rotter, L P SchummA H Steinhart, S R Targan, R J Xavier, C Libioulle, C Sandor, M Lathrop, J Belaiche, O Dewit, I Gut, S Heath, D Laukens, M Mni, P Rutgeerts, A Van Gossum, D Zelenika, D Franchimont, J P Hugot, M de Vos, S Vermeire, E Louis, L R Cardon, C A Anderson, H Drummond, E Nimmo, T Ahmad, N J Prescott, C M Onnie, S A Fisher, J Marchini, J Ghori, S Bumpstead, R Gwilliam, M Tremelling, P Deloukas, J Mansfield, D Jewell, J Satsangi, C G Mathew, M Parkes, M Georges, M J Daly

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Abstract

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development

Original language	English
Pages (from-to)	955 - 962
Number of pages	8
Journal	Nature Genetics
Volume	40
Issue number	8
DOIs	https://doi.org/10.1038/ng.175
Publication status	Published - Aug 2008

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Barrett, J. C., Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., Silverberg, M. S., Taylor, K. D., Barmada, M. M., Bitton, A., Dassopoulos, T., Datta, L. W., Green, T., Griffiths, A. M., Kistner, E. O., Murtha, M. T., Regueiro, M. D., Rotter, J. I., ... Daly, M. J. (2008). Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics, 40(8), 955 - 962. https://doi.org/10.1038/ng.175

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title = "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease",

abstract = "Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development",

author = "Barrett, {J C} and S Hansoul and Nicolae, {D L} and Cho, {J H} and Duerr, {R H} and Rioux, {J D} and Brant, {S R} and Silverberg, {M S} and Taylor, {K D} and Barmada, {M M} and A Bitton and T Dassopoulos and Datta, {L W} and T Green and Griffiths, {A M} and Kistner, {E O} and Murtha, {M T} and Regueiro, {M D} and Rotter, {J I} and Schumm, {L P} and Steinhart, {A H} and Targan, {S R} and Xavier, {R J} and C Libioulle and C Sandor and M Lathrop and J Belaiche and O Dewit and I Gut and S Heath and D Laukens and M Mni and P Rutgeerts and {Van Gossum}, A and D Zelenika and D Franchimont and Hugot, {J P} and {de Vos}, M and S Vermeire and E Louis and Cardon, {L R} and Anderson, {C A} and H Drummond and E Nimmo and T Ahmad and Prescott, {N J} and Onnie, {C M} and Fisher, {S A} and J Marchini and J Ghori and S Bumpstead and R Gwilliam and M Tremelling and P Deloukas and J Mansfield and D Jewell and J Satsangi and Mathew, {C G} and M Parkes and M Georges and Daly, {M J}",

year = "2008",

month = aug,

doi = "10.1038/ng.175",

language = "English",

volume = "40",

pages = "955 -- 962",

journal = "Nature Genetics",

issn = "1546-1718",

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Barrett, JC, Hansoul, S, Nicolae, DL, Cho, JH, Duerr, RH, Rioux, JD, Brant, SR, Silverberg, MS, Taylor, KD, Barmada, MM, Bitton, A, Dassopoulos, T, Datta, LW, Green, T, Griffiths, AM, Kistner, EO, Murtha, MT, Regueiro, MD, Rotter, JI, Schumm, LP, Steinhart, AH, Targan, SR, Xavier, RJ, Libioulle, C, Sandor, C, Lathrop, M, Belaiche, J, Dewit, O, Gut, I, Heath, S, Laukens, D, Mni, M, Rutgeerts, P, Van Gossum, A, Zelenika, D, Franchimont, D, Hugot, JP, de Vos, M, Vermeire, S, Louis, E, Cardon, LR, Anderson, CA, Drummond, H, Nimmo, E, Ahmad, T, Prescott, NJ , Onnie, CM , Fisher, SA, Marchini, J, Ghori, J, Bumpstead, S, Gwilliam, R, Tremelling, M, Deloukas, P, Mansfield, J, Jewell, D, Satsangi, J, Mathew, CG, Parkes, M, Georges, M & Daly, MJ 2008, 'Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease', Nature Genetics, vol. 40, no. 8, pp. 955 - 962. https://doi.org/10.1038/ng.175

TY - JOUR

T1 - Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

AU - Barrett, J C

AU - Hansoul, S

AU - Nicolae, D L

AU - Cho, J H

AU - Duerr, R H

AU - Rioux, J D

AU - Brant, S R

AU - Silverberg, M S

AU - Taylor, K D

AU - Barmada, M M

AU - Bitton, A

AU - Dassopoulos, T

AU - Datta, L W

AU - Green, T

AU - Griffiths, A M

AU - Kistner, E O

AU - Murtha, M T

AU - Regueiro, M D

AU - Rotter, J I

AU - Schumm, L P

AU - Steinhart, A H

AU - Targan, S R

AU - Xavier, R J

AU - Libioulle, C

AU - Sandor, C

AU - Lathrop, M

AU - Belaiche, J

AU - Dewit, O

AU - Gut, I

AU - Heath, S

AU - Laukens, D

AU - Mni, M

AU - Rutgeerts, P

AU - Van Gossum, A

AU - Zelenika, D

AU - Franchimont, D

AU - Hugot, J P

AU - de Vos, M

AU - Vermeire, S

AU - Louis, E

AU - Cardon, L R

AU - Anderson, C A

AU - Drummond, H

AU - Nimmo, E

AU - Ahmad, T

AU - Prescott, N J

AU - Onnie, C M

AU - Fisher, S A

AU - Marchini, J

AU - Ghori, J

AU - Bumpstead, S

AU - Gwilliam, R

AU - Tremelling, M

AU - Deloukas, P

AU - Mansfield, J

AU - Jewell, D

AU - Satsangi, J

AU - Mathew, C G

AU - Parkes, M

AU - Georges, M

AU - Daly, M J

PY - 2008/8

Y1 - 2008/8

N2 - Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development

AB - Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development

U2 - 10.1038/ng.175

DO - 10.1038/ng.175

M3 - Article

SN - 1546-1718

VL - 40

SP - 955

EP - 962

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Abstract

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